PLCE1

PLCE1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2BYE, 2BYF, 2C5L
Dynodwyr
Cyfenwau	PLCE1, NPHS3, PLCE, PPLC, phospholipase C epsilon 1
Dynodwyr allanol	OMIM: 608414 HomoloGene: 9478 GeneCards: PLCE1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • guanyl-nucleotide exchange factor activity • signal transducer activity • GO:0001948, GO:0016582 protein binding • phosphoric diester hydrolase activity • enzyme binding • phospholipase C activity • hydrolase activity • phosphatidylinositol phospholipase C activity • metal ion binding Cydrannau o'r gell • cytosol • Golgi apparatus • bilen • Golgi membrane • Cellbilen • cytoplasm Prosesau biolegol • GO:0007243 intracellular signal transduction • epidermal growth factor receptor signaling pathway • regulation of G protein-coupled receptor signaling pathway • regulation of smooth muscle contraction • lipid metabolism • positive regulation of cytosolic calcium ion concentration • small GTPase mediated signal transduction • regulation of Ras protein signal transduction • glomerulus development • inositol phosphate metabolic process • diacylglycerol biosynthetic process • lipid catabolic process • phospholipase C-activating G protein-coupled receptor signaling pathway • heart development • cytoskeleton organization • regulation of cell growth • regulation of protein kinase activity • cell population proliferation • inositol phosphate-mediated signaling • calcium-mediated signaling • GO:0072468 signal transduction • Ras protein signal transduction • inositol trisphosphate biosynthetic process • phosphatidylinositol-mediated signaling • release of sequestered calcium ion into cytosol Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	51196	n/a
Ensembl	ENSG00000138193	n/a
UniProt	Q9P212	n/a
RefSeq (mRNA)	NM_001165979 NM_001288989 NM_016341	n/a
RefSeq (protein)	NP_001159451 NP_001275918 NP_057425	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PLCE1 yw PLCE1 a elwir hefyd yn Phospholipase C epsilon 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 10, band 10q23.33.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PLCE1.

• PLCE
• PPLC
• NPHS3

Llyfryddiaeth

• "PLCE1 gene in esophageal cancer and interaction with environmental factors. ". Asian Pac J Cancer Prev. 2015. PMID 25854357.
• "Association between PLCE1 rs2274223 A > G polymorphism and cancer risk: proof from a meta-analysis. ". Sci Rep. 2015. PMID 25614244.
• "PLCE1 Promotes Esophageal Cancer Cell Progression by Maintaining the Transcriptional Activity of Snail. ". Neoplasia. 2017. PMID 28147304.
• "Genetic Variations in Phospholipase C-epsilon 1 (PLCE1) and Susceptibility to Colorectal Cancer Risk. ". Biochem Genet. 2016. PMID 27383248.
• "Two novel polymorphisms in PLCE1 are associated with the susceptibility to esophageal squamous cell carcinoma in Chinese population.". Dis Esophagus. 2017. PMID 27061010.