PLCB2

PLCB2
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2FJU, 2ZKM
Dynodwyr
Cyfenwau	PLCB2, PLC-beta-2, phospholipase C beta 2
Dynodwyr allanol	OMIM: 604114 HomoloGene: 20957 GeneCards: PLCB2
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • phosphoric diester hydrolase activity • phospholipase C activity • calcium ion binding • hydrolase activity • signal transducer activity • metal ion binding • phosphatidylinositol phospholipase C activity Cydrannau o'r gell • cytoplasm • cytosol Prosesau biolegol • lipid catabolic process • sensory perception of bitter taste • phospholipid metabolic process • GO:0007243 intracellular signal transduction • inositol phosphate metabolic process • activation of phospholipase C activity • GO:0072468 signal transduction • lipid metabolism • Wnt signaling pathway, calcium modulating pathway • G protein-coupled receptor signaling pathway • inositol trisphosphate biosynthetic process • phosphatidylinositol-mediated signaling • release of sequestered calcium ion into cytosol Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	5330	n/a
Ensembl	ENSG00000137841	n/a
UniProt	Q00722	n/a
RefSeq (mRNA)	NM_001284297 NM_001284298 NM_001284299 NM_004573	n/a
RefSeq (protein)	NP_001271226 NP_001271227 NP_001271228 NP_004564	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PLCB2 yw PLCB2 a elwir hefyd yn Phospholipase C beta 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 15, band 15q15.1.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PLCB2.

• PLC-beta-2

Llyfryddiaeth

• "Alternative splice variants of phospholipase C-beta2 are expressed in platelets: effect on Galphaq-dependent activation and localization. ". Platelets. 2007. PMID 17497434.
• "PLC-beta2 activity on actin-associated polyphosphoinositides promotes migration of differentiating tumoral myeloid precursors. ". Cell Signal. 2007. PMID 17478077.
• "Nuclear factor-κB regulates expression of platelet phospholipase C-β2 (PLCB2). ". Thromb Haemost. 2016. PMID 27465150.
• "PLC-β2 is modulated by low oxygen availability in breast tumor cells and plays a phenotype dependent role in their hypoxia-related malignant potential. ". Mol Carcinog. 2016. PMID 26785288.
• "Superantigen-induced steroid resistance depends on activation of phospholipase Cβ2.". J Immunol. 2013. PMID 23690479.