PLA2G2A

PLA2G2A
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1AYP, 1BBC, 1DB4, 1DB5, 1DCY, 1J1A, 1KQU, 1KVO, 1N28, 1N29, 1POD, 1POE, 3U8B, 3U8D, 3U8H, 3U8I
Dynodwyr
Cyfenwau	PLA2G2A, MOM1, PLA2, PLA2B, PLA2L, PLA2S, PLAS1, sPLA2, phospholipase A2 group IIA
Dynodwyr allanol	OMIM: 172411 HomoloGene: 254 GeneCards: PLA2G2A
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • calcium ion binding • calcium-dependent phospholipase A2 activity • metal ion binding • hydrolase activity • phospholipid binding • phospholipase A2 activity Cydrannau o'r gell • bilen • endoplasmic reticulum membrane • secretory granule • Reticwlwm endoplasmig • perinuclear region of cytoplasm • extracellular exosome • extracellular region • Cellbilen • extracellular space Prosesau biolegol • phosphatidic acid biosynthetic process • phosphatidylserine acyl-chain remodeling • positive regulation of inflammatory response • phosphatidylethanolamine acyl-chain remodeling • lipid metabolism • phosphatidylinositol acyl-chain remodeling • lipid catabolic process • positive regulation of macrophage derived foam cell differentiation • low-density lipoprotein particle remodeling • positive regulation of ERK1 and ERK2 cascade • phosphatidylglycerol acyl-chain remodeling • phosphatidic acid metabolic process • phosphatidylcholine acyl-chain remodeling • GO:0051637 defense response to Gram-positive bacterium • phospholipid metabolic process • antimicrobial humoral response • arachidonic acid secretion Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	5320	n/a
Ensembl	ENSG00000188257	n/a
UniProt	P14555	n/a
RefSeq (mRNA)	NM_001161729 NM_000300 NM_001161727 NM_001161728 NM_001395463	n/a
RefSeq (protein)	NP_000291 NP_001155199 NP_001155200 NP_001155201	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PLA2G2A yw PLA2G2A a elwir hefyd yn Phospholipase A2 group IIA (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 1, band 1p36.13.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PLA2G2A.

• MOM1
• PLA2
• PLA2B
• PLA2L
• PLA2S
• PLAS1
• sPLA2

Llyfryddiaeth

• "sPLA2-IIA Augments Oxidized LDL-Induced MCP-1 Expression in Vitro Through Activation of Akt. ". Cell Physiol Biochem. 2015. PMID 26488172.
• "The association of PLA2G2A single nucleotide polymorphisms with type IIa secretory phospholipase A2 level but not its activity in patients with stable coronary heart disease. ". Gene. 2015. PMID 25794429.
• "Promoting effect of hepatitis B virus on the expressoin of phospholipase A2 group IIA. ". Lipids Health Dis. 2017. PMID 28077172.
• "Molecular dynamics simulations reveal structural insights into inhibitor binding modes and functionality in human Group IIA phospholipase A2. ". Proteins. 2017. PMID 28056488.
• "Factors regulating the substrate specificity of cytosolic phospholipase A2-alpha in vitro.". Biochim Biophys Acta. 2016. PMID 27377346.