PLA2G10

PLA2G10
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1LE6, 1LE7, 4UY1
Dynodwyr
Cyfenwau	PLA2G10, GXPLA2, GXSPLA2, SPLA2, sPLA2-X, phospholipase A2 group X
Dynodwyr allanol	OMIM: 603603 HomoloGene: 2636 GeneCards: PLA2G10
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • calcium ion binding • phospholipase A2 activity • phospholipase activity • metal ion binding • hydrolase activity • phospholipid binding • calcium-dependent phospholipase A2 activity Cydrannau o'r gell • extracellular region • extracellular space Prosesau biolegol • phosphatidic acid biosynthetic process • GO:0051247, GO:0051200 positive regulation of protein metabolic process • phosphatidylserine acyl-chain remodeling • phosphatidylethanolamine acyl-chain remodeling • lysophospholipid transport • lipid metabolism • positive regulation of lipid storage • phosphatidylinositol acyl-chain remodeling • negative regulation of DNA-binding transcription factor activity • axon guidance • lipid catabolic process • positive regulation of prostaglandin secretion • positive regulation of macrophage derived foam cell differentiation • positive regulation of arachidonic acid secretion • phosphatidylglycerol acyl-chain remodeling • negative regulation of cholesterol efflux • cholesterol homeostasis • arachidonic acid metabolic process • phosphatidylcholine acyl-chain remodeling • regulation of macrophage activation • phospholipid metabolic process • arachidonic acid secretion • cellular response to leukemia inhibitory factor Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	8399	n/a
Ensembl	ENSG00000276870 ENSG00000069764	n/a
UniProt	O15496	n/a
RefSeq (mRNA)	NM_003561	n/a
RefSeq (protein)	NP_003552	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PLA2G10 yw PLA2G10 a elwir hefyd yn Phospholipase A2 group X (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 16, band 16p13.12.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PLA2G10.

• SPLA2
• GXPLA2
• GXSPLA2
• sPLA2-X

Llyfryddiaeth

• "Secretory phospholipase A2 activity in serum and cerebrospinal fluid of patients with relapsing-remitting multiple sclerosis. ". J Neuroimmunol. 2013. PMID 23859159.
• "Regulation and function of epithelial secreted phospholipase A2 group X in asthma. ". Am J Respir Crit Care Med. 2013. PMID 23614662.
• "Endogenous secreted phospholipase A2 group X regulates cysteinyl leukotrienes synthesis by human eosinophils. ". J Allergy Clin Immunol. 2016. PMID 26139511.
• "PLA2G10 Gene Variants, sPLA2 Activity, and Coronary Heart Disease Risk. ". Circ Cardiovasc Genet. 2015. PMID 25583995.
• "Group X secreted phospholipase A(2) induces lipid droplet formation and prolongs breast cancer cell survival.". Mol Cancer. 2013. PMID 24070020.