PKLR

PKLR
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2VGB, 2VGF, 2VGG, 2VGI, 4IMA, 4IP7
Dynodwyr
Cyfenwau	PKLR, PK1, PKL, PKR, PKRL, RPK, pyruvate kinase, liver and RBC, pyruvate kinase L/R
Dynodwyr allanol	OMIM: 609712 HomoloGene: 37286 GeneCards: PKLR
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • transferase activity • nucleotide binding • potassium ion binding • metal ion binding • kinase activity • catalytic activity • ATP binding • magnesium ion binding • pyruvate kinase activity Cydrannau o'r gell • cytosol • extracellular exosome • cytoplasm Prosesau biolegol • response to ATP • response to hypoxia • phosphorylation • response to nutrient • canonical glycolysis • response to metal ion • pyruvate biosynthetic process • response to heat • response to glucose • response to lithium ion • ATP biosynthetic process • metabolaeth • response to cAMP • glycolytic process • cellular response to insulin stimulus • cellular response to epinephrine stimulus • carbohydrate metabolic process Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	5313	n/a
Ensembl	ENSG00000262785 ENSG00000143627	n/a
UniProt	P30613	n/a
RefSeq (mRNA)	NM_000298 NM_181871	n/a
RefSeq (protein)	NP_000289 NP_870986	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PKLR yw PKLR a elwir hefyd yn Pyruvate kinase L/R (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 1, band 1q22.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PKLR.

• PK1
• PKL
• PKR
• RPK
• PKRL

Llyfryddiaeth

• "PKLR promotes colorectal cancer liver colonization through induction of glutathione synthesis. ". J Clin Invest. 2016. PMID 26784545.
• "Two Novel Missense Mutations and a 5bp Deletion in the Erythroid-Specific Promoter of the PKLR Gene in Two Unrelated Patients With Pyruvate Kinase Deficient Transfusion-Dependent Chronic Nonspherocytic Hemolytic Anemia. ". Pediatr Blood Cancer. 2016. PMID 26728349.
• "Molecular basis of pyruvate kinase deficiency among Tunisians: description of new mutations affecting coding and noncoding regions in the PKLR gene. ". Int J Lab Hematol. 2017. PMID 28133914.
• "Red cell pyruvate kinase deficiency in Spain: A study of 15 cases. ". Med Clin (Barc). 2017. PMID 27871768.
• "[Analysis and prenatal diagnosis of PKLR gene mutations in a family with pyruvate kinase deficiency].". Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2016. PMID 26829734.