PKIA

PKIA
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1CMK, 1JLU, 1Q8T, 1XH4, 1XH5, 1XH6, 1XH7, 1XH8, 1XH9, 1XHA, 1YDR, 2C1A, 2C1B, 2F7E, 2GNI, 2JDS, 2JDT, 2JDV, 2L1L, 2UVY, 2UVZ, 2UW0, 2UW3, 2UW4, 2UW5, 2UW6, 2UW7, 2UW8, 2VNW, 2VNY, 2VO0, 2VO3, 2VO6, 2VO7, 3AMA, 3AMB, 3L9L, 3L9M, 3L9N, 3MVJ, 3NX8, 3OOG, 3OVV, 3OWP, 3OXT, 3P0M, 3POO, 3VQH, 3WYG, 4AXA, 4IAC, 4IAD, 4IAF, 4IAI, 4IAK, 4IAY, 4IAZ, 4IB0, 4IB1, 4IB3, 4IE9, 4IJ9, 4O21, 4O22, 4WB5, 4WB6, 4WB7, 4WB8, 4Z83, 4Z84, 5DH9, 1Q61, 3X2U, 3X2W, 1Q62, 3X2V, 4UJA, 4UJ9, 4UJB, 4UJ2, 4UJ1
Dynodwyr
Cyfenwau	PKIA, PRKACN1, protein kinase (cAMP-dependent, catalytic) inhibitor alpha, cAMP-dependent protein kinase inhibitor alpha
Dynodwyr allanol	OMIM: 606059 HomoloGene: 7473 GeneCards: PKIA
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • protein kinase inhibitor activity • GO:0001948, GO:0016582 protein binding • cAMP-dependent protein kinase inhibitor activity • protein kinase A catalytic subunit binding • kinase activity Cydrannau o'r gell • cytoplasm • cnewyllyn cell Prosesau biolegol • regulation of G2/M transition of mitotic cell cycle • GO:0048553 negative regulation of catalytic activity • GO:1901227 negative regulation of transcription by RNA polymerase II • negative regulation of cAMP-dependent protein kinase activity • negative regulation of protein kinase activity • negative regulation of protein import into nucleus • negative regulation of protein serine/threonine kinase activity • phosphorylation Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	5569	n/a
Ensembl	ENSG00000171033	n/a
UniProt	P61925	n/a
RefSeq (mRNA)	NM_181839 NM_006823	n/a
RefSeq (protein)	NP_006814 NP_862822 NP_006814.1 NP_862822.1	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PKIA yw PKIA a elwir hefyd yn Protein kinase (CAMP-dependent, catalytic) inhibitor alpha, isoform CRA_a a CAMP-dependent protein kinase inhibitor alpha (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 8, band 8q21.13.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PKIA.

• PRKACN1

Llyfryddiaeth

• "HIV Rev uses a conserved cellular protein export pathway for the nucleocytoplasmic transport of viral RNAs. ". Curr Biol. 1996. PMID 8805303.
• "Evidence for the importance of hydrophobic residues in the interactions between the cAMP-dependent protein kinase catalytic subunit and the protein kinase inhibitors. ". J Biol Chem. 1994. PMID 8027074.
• "Primary-structure requirements for inhibition by the heat-stable inhibitor of the cAMP-dependent protein kinase. ". Proc Natl Acad Sci U S A. 1986. PMID 3456605.
• "Inhibition of protein kinase-A by overexpression of the cloned human protein kinase inhibitor. ". Mol Endocrinol. 1991. PMID 1770951.
• "Mutants of protein kinase A that mimic the ATP-binding site of protein kinase B (AKT).". J Mol Biol. 2003. PMID 12798691.