PITX1

PITX1
Dynodwyr
Cyfenwau	PITX1, BFT, CCF, LBNBG, POTX, PTX1, paired like homeodomain 1
Dynodwyr allanol	OMIM: 602149 HomoloGene: 20584 GeneCards: PITX1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • DNA binding • sequence-specific DNA binding • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • GO:0001948, GO:0016582 protein binding • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Cydrannau o'r gell • cytoplasm • transcription regulator complex • nucleolus • cnewyllyn cell Prosesau biolegol • skeletal system development • pituitary gland development • GO:0009373 regulation of transcription, DNA-templated • anatomical structure morphogenesis • transcription by RNA polymerase II • hindlimb morphogenesis • transcription, DNA-templated • multicellular organism development • cartilage development • myoblast fate commitment • GO:0045996 negative regulation of transcription, DNA-templated • branchiomeric skeletal muscle development • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • embryonic hindlimb morphogenesis Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	5307	n/a
Ensembl	ENSG00000069011	n/a
UniProt	P78337	n/a
RefSeq (mRNA)	NM_002653	n/a
RefSeq (protein)	NP_002644	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PITX1 yw PITX1 a elwir hefyd yn Pituitary homeobox 1 a Paired like homeodomain 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 5, band 5q31.1.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PITX1.

• BFT
• CCF
• POTX
• PTX1
• LBNBG

Llyfryddiaeth

• "PITX1, a specificity determinant in the HIF-1α-mediated transcriptional response to hypoxia. ". Cell Cycle. 2014. PMID 25558831.
• "The Liebenberg syndrome: in depth analysis of the original family. ". J Hand Surg Eur Vol. 2014. PMID 23940102.
• "Impact of G-quadruplex loop conformation in the PITX1 mRNA on protein and small molecule interaction. ". Biochem Biophys Res Commun. 2017. PMID 28412358.
• "Clinicopathological features and pituitary homeobox 1 gene expression in the progression and prognosis of cutaneous malignant melanoma. ". Kaohsiung J Med Sci. 2016. PMID 27742032.
• "Strong expression of paired-like homeodomain transcription factor 1 (PITX1) is associated with a favorable outcome in human osteosarcoma.". Tumour Biol. 2015. PMID 25936343.