PIN1

PIN1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1F8A, 1I6C, 1I8G, 1I8H, 1NMV, 1NMW, 1PIN, 1ZCN, 2F21, 2ITK, 2KBU, 2KCF, 2LB3, 2M8I, 2M8J, 2M9E, 2M9F, 2M9I, 2M9J, 2Q5A, 2RUC, 2RUD, 2XP3, 2XP4, 2XP5, 2XP6, 2XP7, 2XP8, 2XP9, 2XPA, 2XPB, 2ZQS, 2ZQT, 2ZQU, 2ZQV, 2ZR4, 2ZR5, 2ZR6, 3I6C, 3IK8, 3IKD, 3IKG, 3JYJ, 3KAB, 3KAC, 3KAD, 3KAF, 3KAG, 3KAH, 3KAI, 3KCE, 3NTP, 3ODK, 3OOB, 3TC5, 3TCZ, 3TDB, 3WH0, 4GWT, 4GWV, 4QIB, 4TNS, 4TYO, 4U84, 4U85, 4U86, 2RUQ, 2N1O, 2RUR
Dynodwyr
Cyfenwau	PIN1, DOD, UBL5, peptidylprolyl cis/trans isomerase, NIMA-interacting 1
Dynodwyr allanol	OMIM: 601052 HomoloGene: 4531 GeneCards: PIN1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GTPase activating protein binding • beta-catenin binding • isomerase activity • peptidyl-prolyl cis-trans isomerase activity • GO:0001948, GO:0016582 protein binding • mitogen-activated protein kinase kinase binding • cytoskeletal motor activity • phosphoserine residue binding • phosphothreonine residue binding • tau protein binding • phosphoprotein binding • cis-trans isomerase activity Cydrannau o'r gell • cytoplasm • cytosol • nuclear speck • midbody • mitocondria • neuron projection • cnewyllyn cell • nucleoplasm • glutamatergic synapse • postsynaptic cytosol Prosesau biolegol • GO:1904089 negative regulation of neuron apoptotic process • positive regulation of protein phosphorylation • regulation of cytokinesis • positive regulation of protein dephosphorylation • GO:1903363 negative regulation of protein catabolic process • positive regulation of canonical Wnt signaling pathway • synapse organization • negative regulation of cell motility • protein stabilization • negative regulation of transforming growth factor beta receptor signaling pathway • negative regulation of protein binding • protein peptidyl-prolyl isomerization • regulation of protein localization to nucleus • GO:0032320, GO:0032321, GO:0032855, GO:0043089, GO:0032854 positive regulation of GTPase activity • positive regulation of neuron apoptotic process • positive regulation of ubiquitin-protein transferase activity • neuron differentiation • negative regulation of ERK1 and ERK2 cascade • cell cycle • negative regulation of type I interferon production • positive regulation of cell growth involved in cardiac muscle cell development • regulation of pathway-restricted SMAD protein phosphorylation • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • regulation of mitotic nuclear division • regulation of signal transduction by p53 class mediator • regulation of protein phosphorylation • regulation of gene expression • positive regulation of protein binding • microtubule polymerization • response to hypoxia • regulation of protein stability • negative regulation of amyloid-beta formation Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	5300	n/a
Ensembl	ENSG00000127445	n/a
UniProt	Q13526	n/a
RefSeq (mRNA)	NM_006221	n/a
RefSeq (protein)	NP_006212	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PIN1 yw PIN1 a elwir hefyd yn Peptidylprolyl isomerase a Peptidylprolyl cis/trans isomerase, NIMA-interacting 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 19, band 19p13.2.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PIN1.

• DOD
• UBL5

Llyfryddiaeth

• "Understanding the role of PIN1 in hepatocellular carcinoma. ". World J Gastroenterol. 2016. PMID 28018099.
• "Pin1 and secondary hyperparathyroidism of chronic kidney disease: gene polymorphisms and protein levels. ". Ren Fail. 2017. PMID 27876426.
• "Parallel folding pathways of Fip35 WW domain explained by infrared spectra and their computer simulation. ". FEBS Lett. 2017. PMID 28881468.
• "Effects of naturally occurring charged mutations on the structure, stability, and binding of the Pin1 WW domain. ". Biochem Biophys Res Commun. 2017. PMID 28431929.
• "Down-regulation of Pin1 in Temporal Lobe Epilepsy Patients and Mouse Model.". Neurochem Res. 2017. PMID 28239767.