PIK3R2

PIK3R2
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2KT1, 2XS6, 3MTT, 3O5Z
Dynodwyr
Cyfenwau	PIK3R2, MPPH, MPPH1, P85B, p85, p85-BETA, phosphoinositide-3-kinase regulatory subunit 2
Dynodwyr allanol	OMIM: 603157 HomoloGene: 3687 GeneCards: PIK3R2
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • phosphatidylinositol 3-kinase regulator activity • receptor tyrosine kinase binding • 1-phosphatidylinositol-3-kinase regulator activity • GO:0001948, GO:0016582 protein binding • protein heterodimerization activity • protein phosphatase binding • GO:0005097, GO:0005099, GO:0005100 GTPase activator activity • phosphatidylinositol-4,5-bisphosphate 3-kinase activity • phosphotyrosine residue binding • 1-phosphatidylinositol-3-kinase activity Cydrannau o'r gell • cytosol • phosphatidylinositol 3-kinase complex • cnewyllyn cell Prosesau biolegol • Fc-gamma receptor signaling pathway involved in phagocytosis • cellular glucose homeostasis • response to endoplasmic reticulum stress • Fc-epsilon receptor signaling pathway • phosphatidylinositol phosphate biosynthetic process • vascular endothelial growth factor receptor signaling pathway • regulation of autophagy • regulation of phosphatidylinositol 3-kinase activity • cellular response to insulin stimulus • protein transport • phosphatidylinositol 3-kinase signaling • T cell receptor signaling pathway • regulation of small GTPase mediated signal transduction • phosphatidylinositol-mediated signaling • leukocyte migration • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • GO:0072468 signal transduction • GO:1901047 insulin receptor signaling pathway • GO:0032320, GO:0032321, GO:0032855, GO:0043089, GO:0032854 positive regulation of GTPase activity • phosphatidylinositol-3-phosphate biosynthetic process • negative regulation of MAPK cascade • positive regulation of protein kinase B signaling • positive regulation of protein import into nucleus • phosphatidylinositol biosynthetic process Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	5296	n/a
Ensembl	n/a	n/a
UniProt	O00459	n/a
RefSeq (mRNA)	NM_005027	n/a
RefSeq (protein)	NP_005018	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PIK3R2 yw PIK3R2 a elwir hefyd yn Phosphoinositide-3-kinase regulatory subunit 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 19, band 19p13.11.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PIK3R2.

• p85
• MPPH
• P85B
• MPPH1
• p85-BETA

Llyfryddiaeth

• "Structure of the iSH2 domain of human phosphatidylinositol 3-kinase p85β subunit reveals conformational plasticity in the interhelical turn region. ". Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010. PMID 21139197.
• "Heterologous SH3-p85beta inhibits influenza A virus replication. ". Virol J. 2010. PMID 20653952.
• "De novo PIK3R2 variant causes polymicrogyria, corpus callosum hyperplasia and focal cortical dysplasia. ". Eur J Hum Genet. 2016. PMID 26860062.
• "Characterisation of mutations of the phosphoinositide-3-kinase regulatory subunit, PIK3R2, in perisylvian polymicrogyria: a next-generation sequencing study. ". Lancet Neurol. 2015. PMID 26520804.
• "X-ray structure of the SH3 domain of the phosphoinositide 3-kinase p85β subunit.". Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011. PMID 22102226.