PIK3R1

PIK3R1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1A0N, 1AZG, 1H9O, 1PBW, 1PHT, 1PIC, 1PKS, 1PKT, 2IUG, 2IUH, 2IUI, 2RD0, 2V1Y, 3HHM, 3HIZ, 3I5R, 3I5S, 4A55, 4JPS, 4L1B, 4L23, 4L2Y, 4OVU, 4OVV, 4WAF, 5AUL
Dynodwyr
Cyfenwau	PIK3R1, AGM7, GRB1, IMD36, p85, p85-ALPHA, phosphoinositide-3-kinase regulatory subunit 1, PI3KR1
Dynodwyr allanol	OMIM: 171833 HomoloGene: 7889 GeneCards: PIK3R1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • ErbB-3 class receptor binding • phosphatidylinositol 3-kinase regulator activity • insulin-like growth factor receptor binding • transmembrane receptor protein tyrosine kinase adaptor activity • insulin receptor binding • neurotrophin TRKA receptor binding • phosphatidylinositol 3-kinase regulatory subunit binding • transcription factor binding • insulin binding • phosphatidylinositol 3-kinase binding • 1-phosphatidylinositol-3-kinase regulator activity • GO:0001948, GO:0016582 protein binding • protein heterodimerization activity • insulin receptor substrate binding • protein phosphatase binding • 1-phosphatidylinositol-3-kinase activity • phosphatidylinositol-4,5-bisphosphate 3-kinase activity • phosphotyrosine residue binding Cydrannau o'r gell • cytoplasm • cytosol • phosphatidylinositol 3-kinase complex • phosphatidylinositol 3-kinase complex, class IA • bilen • cell-cell junction • cis-Golgi network • Cellbilen • cnewyllyn cell • perinuclear endoplasmic reticulum membrane • GO:0009327 protein-containing complex Prosesau biolegol • positive regulation of glucose import • insulin-like growth factor receptor signaling pathway • negative regulation of cell adhesion • positive regulation of endoplasmic reticulum unfolded protein response • epidermal growth factor receptor signaling pathway • Fc-gamma receptor signaling pathway involved in phagocytosis • negative regulation of osteoclast differentiation • positive regulation of cell migration • cellular glucose homeostasis • cellular response to UV • T cell costimulation • protein stabilization • negative regulation of apoptotic process • response to endoplasmic reticulum stress • regulation of stress fiber assembly • negative regulation of cell-matrix adhesion • platelet activation • Fc-epsilon receptor signaling pathway • protein phosphorylation • phosphatidylinositol phosphate biosynthetic process • vascular endothelial growth factor receptor signaling pathway • growth hormone receptor signaling pathway • regulation of phosphatidylinositol 3-kinase activity • intrinsic apoptotic signaling pathway in response to DNA damage • cellular response to insulin stimulus • positive regulation of tumor necrosis factor production • positive regulation of RNA splicing • phosphatidylinositol biosynthetic process • protein transport • B cell differentiation • GO:0022415 viral process • T cell receptor signaling pathway • extrinsic apoptotic signaling pathway via death domain receptors • phosphatidylinositol-mediated signaling • leukocyte migration • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • GO:0072468 signal transduction • phosphatidylinositol 3-kinase signaling • phosphatidylinositol-3-phosphate biosynthetic process • ERBB2 signaling pathway • GO:1901047 insulin receptor signaling pathway • axon guidance • GO:1903104 regulation of insulin receptor signaling pathway • interleukin-7-mediated signaling pathway • GO:0015915 transport • regulation of protein localization to plasma membrane • positive regulation of protein localization to plasma membrane • G protein-coupled receptor signaling pathway • positive regulation of protein kinase B signaling • protein import into nucleus • positive regulation of phosphatidylinositol 3-kinase signaling • cytokine-mediated signaling pathway • positive regulation of protein import into nucleus Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	5295	n/a
Ensembl	ENSG00000145675	n/a
UniProt	P27986	n/a
RefSeq (mRNA)	NM_001242466 NM_181504 NM_181523 NM_181524	n/a
RefSeq (protein)	NP_001229395 NP_852556 NP_852664 NP_852665	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PIK3R1 yw PIK3R1 a elwir hefyd yn Phosphoinositide-3-kinase regulatory subunit 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 5, band 5q13.1.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PIK3R1.

• p85
• AGM7
• GRB1
• IMD36
• p85-ALPHA

Llyfryddiaeth

• "Dominant Splice Site Mutations in PIK3R1 Cause Hyper IgM Syndrome, Lymphadenopathy and Short Stature. ". J Clin Immunol. 2016. PMID 27076228.
• "Reduced germinal center follicular helper T cells but normal follicular regulatory T cells in the tonsils of a patient with a mutation in the PI3KR1 gene. ". Clin Immunol. 2016. PMID 26827886.
• "Iris Malformation and Anterior Segment Dysgenesis in Mice and Humans With a Mutation in PI 3-Kinase. ". Invest Ophthalmol Vis Sci. 2017. PMID 28632845.
• "Aberrant low expression of p85α in stromal fibroblasts promotes breast cancer cell metastasis through exosome-mediated paracrine Wnt10b. ". Oncogene. 2017. PMID 28394344.
• "Gain-of-function mutation in PIK3R1 in a patient with a narrow clinical phenotype of respiratory infections.". Clin Immunol. 2016. PMID 27693481.