PIK3C3

PIK3C3
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 3IHY, 3LS8, 4OYS, 4PH4, 4UWF, 4UWG, 4UWH, 4UWL, 5ANL
Dynodwyr
Cyfenwau	PIK3C3, VPS34, hVps34, phosphatidylinositol 3-kinase catalytic subunit type 3
Dynodwyr allanol	OMIM: 602609 HomoloGene: 1986 GeneCards: PIK3C3
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • transferase activity • protein kinase activity • nucleotide binding • 1-phosphatidylinositol-3-kinase activity • GO:0001948, GO:0016582 protein binding • phosphatidylinositol 3-kinase activity • ATP binding • kinase activity Cydrannau o'r gell • cytosol • endosome • late endosome • phagocytic vesicle membrane • bilen • phosphatidylinositol 3-kinase complex, class III • autophagosome • midbody • phagocytic vesicle • GO:0035085 axoneme • GO:0016023 cytoplasmic vesicle • autolysosome • phagophore assembly site • peroxisome • phosphatidylinositol 3-kinase complex, class III, type I • phosphatidylinositol 3-kinase complex, class III, type II • cytoplasm • intracellular anatomical structure Prosesau biolegol • cellular response to glucose starvation • regulation of cytokinesis • phosphorylation • protein processing • response to leucine • cytokinesis • endosome organization • Cellraniad • phosphatidylinositol-3-phosphate biosynthetic process • phosphatidylinositol phosphate biosynthetic process • early endosome to late endosome transport • phosphatidylinositol biosynthetic process • cell cycle • toll-like receptor 9 signaling pathway • macroautophagy • regulation of protein secretion • protein localization to phagophore assembly site • cellular response to starvation • protein lipidation • autophagy • autophagosome assembly • protein phosphorylation • endocytosis • autophagy of peroxisome • phosphatidylinositol-mediated signaling • interleukin-7-mediated signaling pathway Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	5289	n/a
Ensembl	ENSG00000078142	n/a
UniProt	Q8NEB9	n/a
RefSeq (mRNA)	NM_001308020 NM_002647	n/a
RefSeq (protein)	NP_001294949 NP_002638	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PIK3C3 yw PIK3C3 a elwir hefyd yn Phosphatidylinositol 3-kinase catalytic subunit type 3 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 18, band 18q12.3.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PIK3C3.

• VPS34
• Vps34
• hVps34

Llyfryddiaeth

• "Promoter variant of PIK3C3 is associated with autoimmunity against Ro and Sm epitopes in African-American lupus patients. ". J Biomed Biotechnol. 2010. PMID 20671926.
• "Activation of PI3K-AKT pathway in oral epithelial dysplasia and early cancer of tongue. ". Bull Tokyo Dent Coll. 2009. PMID 19887755.
• "Endosomal Phosphatidylinositol 3-Kinase Is Essential for Canonical GPCR Signaling. ". Mol Pharmacol. 2017. PMID 27821547.
• "Discovery of (2S)-8-[(3R)-3-methylmorpholin-4-yl]-1-(3-methyl-2-oxobutyl)-2-(trifluoromethyl)-3,4-dihydro-2H-pyrimido[1,2-a]pyrimidin-6-one: a novel potent and selective inhibitor of Vps34 for the treatment of solid tumors. ". J Med Chem. 2015. PMID 25402320.
• "Regulation of PIK3C3/VPS34 complexes by MTOR in nutrient stress-induced autophagy.". Autophagy. 2013. PMID 24013218.