PIK3C2A

PIK3C2A
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2AR5, 2IWL, 2REA, 2RED
Dynodwyr
Cyfenwau	PIK3C2A, CPK, PI3-K-C2(ALPHA), PI3-K-C2A, PI3K-C2-alpha, PI3K-C2alpha, phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha, OCSKD
Dynodwyr allanol	OMIM: 603601 HomoloGene: 20581 GeneCards: PIK3C2A
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • transferase activity • nucleotide binding • 1-phosphatidylinositol-3-kinase activity • 1-phosphatidylinositol-4-phosphate 3-kinase activity • kinase activity • phosphatidylinositol binding • phosphatidylinositol 3-kinase activity • ATP binding Cydrannau o'r gell • cytoplasm • fesigl • cytosol • phosphatidylinositol 3-kinase complex • Golgi apparatus • bilen • Cellbilen • extracellular exosome • GO:0016023 cytoplasmic vesicle • clathrin-coated vesicle • cnewyllyn cell Prosesau biolegol • GO:1901047 insulin receptor signaling pathway • endocytosis • epidermal growth factor receptor signaling pathway • phosphorylation • phosphatidylinositol phosphate biosynthetic process • clathrin coat assembly • phosphatidylinositol biosynthetic process • platelet-derived growth factor receptor signaling pathway • phosphatidylinositol-mediated signaling • vascular associated smooth muscle contraction • exocytosis • phosphatidylinositol-3-phosphate biosynthetic process • membrane organization • phosphatidylinositol 3-kinase signaling • cell migration • positive regulation of cell migration involved in sprouting angiogenesis Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	5286	n/a
Ensembl	ENSG00000011405	n/a
UniProt	O00443	n/a
RefSeq (mRNA)	NM_002645 NM_001321378 NM_001321380 NM_001386870	n/a
RefSeq (protein)	NP_001308307 NP_001308309 NP_002636	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PIK3C2A yw PIK3C2A a elwir hefyd yn Phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 11, band 11p15.1.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PIK3C2A.

• CPK
• PI3-K-C2A
• PI3K-C2alpha
• PI3K-C2-alpha
• PI3-K-C2(ALPHA)

Llyfryddiaeth

• "Ablation of phosphoinositide-3-kinase class II alpha suppresses hepatoma cell proliferation. ". Biochem Biophys Res Commun. 2009. PMID 19591801.
• "Down-regulation of class II phosphoinositide 3-kinase alpha expression below a critical threshold induces apoptotic cell death. ". Mol Cancer Res. 2008. PMID 18403640.
• "PI3K-C2α knockdown decreases autophagy and maturation of endocytic vesicles. ". PLoS One. 2017. PMID 28910396.
• "High-Throughput Small Interfering RNA Screening Identifies Phosphatidylinositol 3-Kinase Class II Alpha as Important for Production of Human Cytomegalovirus Virions. ". J Virol. 2016. PMID 27412598.
• "The class II phosphatidylinositol 3-phosphate kinase PIK3C2A promotes Shigella flexneri dissemination through formation of vacuole-like protrusions.". Infect Immun. 2015. PMID 25667265.