PICK1

PICK1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2GZV
Dynodwyr
Cyfenwau	PICK1, PICK, PRKCABP, protein interacting with PRKCA 1
Dynodwyr allanol	OMIM: 605926 HomoloGene: 7470 GeneCards: PICK1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • protein domain specific binding • Arp2/3 complex binding • metal ion binding • actin filament binding • protein C-terminus binding • GO:0001948, GO:0016582 protein binding • identical protein binding • enzyme binding • actin binding • signaling receptor binding • G protein-coupled receptor binding • protein kinase C binding • phospholipid binding Cydrannau o'r gell • cytoplasm • endocytic vesicle membrane • postsynaptic membrane • Golgi apparatus • GO:0097483, GO:0097481 postsynaptic density • bilen • Cellbilen • synapse • cell junction • perinuclear region of cytoplasm • neuron projection • Cytosgerbwd • presynaptic membrane • mitocondria • cytosol • aggresome • synaptic vesicle • trans-Golgi network membrane • postsynaptic early endosome Prosesau biolegol • cellular response to glucose starvation • glial cell development • retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum • positive regulation of receptor internalization • neuronal ion channel clustering • regulation of Arp2/3 complex-mediated actin nucleation • monoamine transport • receptor clustering • DNA methylation involved in gamete generation • negative regulation of Arp2/3 complex-mediated actin nucleation • dendritic spine organization • dendritic spine maintenance • protein phosphorylation • protein kinase C-activating G protein-coupled receptor signaling pathway • long-term depression • cellular response to decreased oxygen levels • DNA methylation involved in embryo development • intracellular protein transport Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	9463	n/a
Ensembl	ENSG00000100151	n/a
UniProt	Q9NRD5	n/a
RefSeq (mRNA)	NM_001039583 NM_001039584 NM_012407	n/a
RefSeq (protein)	NP_001034672 NP_001034673 NP_036539 NP_001034672.1 NP_001034673.1 NP_036539.1	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PICK1 yw PICK1 a elwir hefyd yn PRKCA-binding protein a Protein interacting with PRKCA 1, isoform CRA_a (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 22, band 22q13.1.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PICK1.

• PICK
• PRKCABP

Llyfryddiaeth

• "PICK1 links Argonaute 2 to endosomes in neuronal dendrites and regulates miRNA activity. ". EMBO Rep. 2014. PMID 24723684.
• "PICK1 promotes caveolin-dependent degradation of TGF-β type I receptor. ". Cell Res. 2012. PMID 22710801.
• "Protein interacting with C kinase 1 suppresses invasion and anchorage-independent growth of astrocytic tumor cells. ". Mol Biol Cell. 2015. PMID 26466675.
• "PICK1 is implicated in organelle motility in an Arp2/3 complex-independent manner. ". Mol Biol Cell. 2015. PMID 25657323.
• "Protein interacting with C-kinase 1 (PICK1) binding promiscuity relies on unconventional PSD-95/discs-large/ZO-1 homology (PDZ) binding modes for nonclass II PDZ ligands.". J Biol Chem. 2014. PMID 25023278.