PIAS1

PIAS1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1V66
Dynodwyr
Cyfenwau	PIAS1, DDXBP1, GBP, GU/RH-II, ZMIZ3, protein inhibitor of activated STAT 1
Dynodwyr allanol	OMIM: 603566 HomoloGene: 22953 GeneCards: PIAS1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • DNA binding • GO:0001106 transcription corepressor activity • GO:0001105 transcription coactivator activity • zinc ion binding • transcription factor binding • metal ion binding • SUMO ligase activity • GO:0001948, GO:0016582 protein binding • androgen receptor binding • enzyme binding • ubiquitin protein ligase binding • protein domain specific binding • SUMO transferase activity • transferase activity • protein C-terminus binding Cydrannau o'r gell • PML body • nuclear speck • nucleoplasm • cnewyllyn cell Prosesau biolegol • androgen receptor signaling pathway • receptor signaling pathway via JAK-STAT • GO:0009373 regulation of transcription, DNA-templated • GO:1901227 negative regulation of transcription by RNA polymerase II • protein sumoylation • transcription, DNA-templated • regulation of interferon-gamma-mediated signaling pathway • regulation of cell population proliferation • fat cell differentiation • positive regulation of proteasomal ubiquitin-dependent protein catabolic process • visual learning • negative regulation of apoptotic process • positive regulation of smooth muscle cell differentiation • spermatogenesis • positive regulation of protein sumoylation • protein-DNA complex assembly • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • G1/S transition of mitotic cell cycle Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	8554	n/a
Ensembl	ENSG00000033800	n/a
UniProt	O75925	n/a
RefSeq (mRNA)	NM_016166 NM_001320687	n/a
RefSeq (protein)	NP_001307616 NP_057250	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PIAS1 yw PIAS1 a elwir hefyd yn Protein inhibitor of activated STAT 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 15, band 15q23.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PIAS1.

• GBP
• ZMIZ3
• DDXBP1
• GU/RH-II

Llyfryddiaeth

• "PIAS1 is a crucial factor for prostate cancer cell survival and a valid target in docetaxel resistant cells. ". Oncotarget. 2014. PMID 25474038.
• "PIAS1 regulates breast tumorigenesis through selective epigenetic gene silencing. ". PLoS One. 2014. PMID 24586797.
• "Identification of the SUMO E3 ligase PIAS1 as a potential survival biomarker in breast cancer. ". PLoS One. 2017. PMID 28493978.
• "Hepatitis B virus surface protein-induced hPIAS1 transcription requires TAL1, E47, MYOG, NFI, and MAPK signal pathways. ". Biol Chem. 2016. PMID 27276529.
• "SUMO Ligase Protein Inhibitor of Activated STAT1 (PIAS1) Is a Constituent Promyelocytic Leukemia Nuclear Body Protein That Contributes to the Intrinsic Antiviral Immune Response to Herpes Simplex Virus 1.". J Virol. 2016. PMID 27099310.