PHGDH

PHGDH
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2G76
Dynodwyr
Cyfenwau	PHGDH, 3-PGDH, 3PGDH, HEL-S-113, NLS, PDG, PGAD, PGD, PGDH, PHGDHD, SERA, NLS1, Phosphoglycerate dehydrogenase
Dynodwyr allanol	OMIM: 606879 HomoloGene: 39318 GeneCards: PHGDH
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0050229 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor • NAD binding • phosphoglycerate dehydrogenase activity • electron transfer activity • oxidoreductase activity • L-malate dehydrogenase activity Cydrannau o'r gell • cytosol • extracellular exosome Prosesau biolegol • L-serine biosynthetic process • brain development • metabolaeth • cellular amino acid biosynthetic process • electron transport chain • cellular amino acid metabolic process • glutamine metabolic process • glycine metabolic process • L-serine metabolic process • threonine metabolic process • gamma-aminobutyric acid metabolic process • regulation of gene expression • taurine metabolic process • spinal cord development • glial cell development • neural tube development • neurogenesis • neuron projection development • G1 to G0 transition Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	26227	n/a
Ensembl	ENSG00000092621	n/a
UniProt	O43175	n/a
RefSeq (mRNA)	NM_006623 NM_032692	n/a
RefSeq (protein)	NP_006614	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PHGDH yw PHGDH a elwir hefyd yn Phosphoglycerate dehydrogenase (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 1, band 1p12.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PHGDH.

• NLS
• PDG
• PGD
• NLS1
• PGAD
• PGDH
• SERA
• 3PGDH
• 3-PGDH
• PHGDHD
• HEL-S-113

Llyfryddiaeth

• "Neu-Laxova syndrome, an inborn error of serine metabolism, is caused by mutations in PHGDH. ". Am J Hum Genet. 2014. PMID 24836451.
• "PHGDH amplification and altered glucose metabolism in human melanoma. ". Pigment Cell Melanoma Res. 2011. PMID 21981974.
• "PHGDH is an independent prognosis marker and contributes cell proliferation, migration and invasion in human pancreatic cancer. ". Gene. 2018. PMID 29128633.
• "Infantile Serine Biosynthesis Defect Due to Phosphoglycerate Dehydrogenase Deficiency: Variability in Phenotype and Treatment Response, Novel Mutations, and Diagnostic Challenges. ". J Child Neurol. 2017. PMID 28135894.
• "High level PHGDH expression in breast is predominantly associated with keratin 5-positive cell lineage independently of malignancy.". Mol Oncol. 2015. PMID 26026368.