PHF6

PHF6
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 4NN2, 4R7A
Dynodwyr
Cyfenwau	PHF6, BFLS, BORJ, CENP-31, PHD finger protein 6
Dynodwyr allanol	OMIM: 300414 HomoloGene: 12375 GeneCards: PHF6
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • tubulin binding • enzyme binding • scaffold protein binding • DNA binding • ribonucleoprotein complex binding • GO:0031493 histone binding • phosphoprotein binding • histone deacetylase binding • GO:0001948, GO:0016582 protein binding • metal ion binding • RNA binding • GO:0001078, GO:0001214, GO:0001206 DNA-binding transcription repressor activity, RNA polymerase II-specific • sequence-specific DNA binding Cydrannau o'r gell • nucleolus • chromosome, centromeric region • cnewyllyn cell • kinetochore • nucleoplasm • Cromosom Prosesau biolegol • GO:0009373 regulation of transcription, DNA-templated • transcription, DNA-templated • GO:1901227 negative regulation of transcription by RNA polymerase II • blastocyst hatching Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	84295	n/a
Ensembl	ENSG00000156531	n/a
UniProt	Q8IWS0	n/a
RefSeq (mRNA)	NM_032458 NM_001015877 NM_032335	n/a
RefSeq (protein)	NP_001015877 NP_115711 NP_115834	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PHF6 yw PHF6 a elwir hefyd yn PHD finger protein 6 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom X dynol, band Xq26.2.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PHF6.

• BFLS
• BORJ
• CENP-31

Llyfryddiaeth

• "Females with de novo aberrations in PHF6: clinical overlap of Borjeson-Forssman-Lehmann with Coffin-Siris syndrome. ". Am J Med Genet C Semin Med Genet. 2014. PMID 25099957.
• "MicroRNA-128-3p is a novel oncomiR targeting PHF6 in T-cell acute lymphoblastic leukemia. ". Haematologica. 2014. PMID 24895337.
• "The sub-nucleolar localization of PHF6 defines its role in rDNA transcription and early processing events. ". Eur J Hum Genet. 2016. PMID 27165002.
• "The potential role of PHF6 as an oncogene: a genotranscriptomic/proteomic meta-analysis. ". Tumour Biol. 2016. PMID 26561469.
• "A genome-scale in vivo loss-of-function screen identifies Phf6 as a lineage-specific regulator of leukemia cell growth.". Genes Dev. 2015. PMID 25737277.