PGLYRP1

PGLYRP1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1YCK
Dynodwyr
Cyfenwau	PGLYRP1, PGLYRP, PGRP, PGRP-S, PGRPS, TAG7, TNFSF3L, peptidoglycan recognition protein 1
Dynodwyr allanol	OMIM: 604963 HomoloGene: 74539 GeneCards: PGLYRP1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • zinc ion binding • peptidoglycan immune receptor activity • N-acetylmuramoyl-L-alanine amidase activity • peptidoglycan binding Cydrannau o'r gell • extracellular exosome • extracellular region • specific granule lumen • phagocytic vesicle lumen • tertiary granule lumen • extracellular space Prosesau biolegol • peptidoglycan catabolic process • negative regulation of natural killer cell differentiation involved in immune response • negative regulation of interferon-gamma production • innate immune response • negative regulation of inflammatory response • defense response to bacterium • GO:0046730, GO:0046737, GO:0046738, GO:0046736 immune response • detection of bacterium • immune system process • GO:0051637 defense response to Gram-positive bacterium • pattern recognition receptor signaling pathway • antimicrobial humoral response • neutrophil degranulation • positive regulation of cytolysis in other organism • antimicrobial humoral immune response mediated by antimicrobial peptide • response to bacterium • killing of cells of other organism Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	8993	n/a
Ensembl	ENSG00000008438	n/a
UniProt	O75594	n/a
RefSeq (mRNA)	NM_005091	n/a
RefSeq (protein)	NP_005082	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PGLYRP1 yw PGLYRP1 a elwir hefyd yn Peptidoglycan recognition protein 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 19, band 19q13.32.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PGLYRP1.

• PGRP
• TAG7
• PGRPS
• PGLYRP
• PGRP-S
• TNFSF3L

Llyfryddiaeth

• "Crystal structure of human peptidoglycan recognition protein S (PGRP-S) at 1.70 A resolution. ". J Mol Biol. 2005. PMID 15769462.
• "A new role for PGRP-S (Tag7) in immune defense: lymphocyte migration is induced by a chemoattractant complex of Tag7 with Mts1. ". Cell Cycle. 2015. PMID 26654597.
• "The Tag7-Hsp70 cytotoxic complex induces tumor cell necroptosis via permeabilisation of lysosomes and mitochondria. ". Biochimie. 2016. PMID 26796882.
• "The association between peptidoglycan recognition protein-1 and coronary and peripheral atherosclerosis: Observations from the Dallas Heart Study. ". Atherosclerosis. 2009. PMID 18774573.
• "Human peptidoglycan recognition protein S is an effector of neutrophil-mediated innate immunity.". Blood. 2005. PMID 15956276.