PGC

PGC
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1AVF, 1HTR
Dynodwyr
Cyfenwau	PGC, PEPC, PGII, gastricsin, progastricsin (pepsinogen C), progastricsin
Dynodwyr allanol	OMIM: 169740 HomoloGene: 55669 GeneCards: PGC
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0070122 peptidase activity • hydrolase activity • aspartic-type endopeptidase activity Cydrannau o'r gell • extracellular region • extracellular space Prosesau biolegol • positive regulation of antibacterial peptide production • Treulio bwyd • GO:0044257 protein catabolic process • proteolysis • autophagy Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	5225	n/a
Ensembl	ENSG00000096088	n/a
UniProt	P20142	n/a
RefSeq (mRNA)	NM_002630 NM_001166424	n/a
RefSeq (protein)	NP_001159896 NP_002621	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PGC yw PGC a elwir hefyd yn Progastricsin a Gastricsin (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 6, band 6p21.1.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PGC.

• PEPC
• PGII

Llyfryddiaeth

• "PGC TagSNP and its interaction with H. pylori and relation with gene expression in susceptibility to gastric carcinogenesis. ". PLoS One. 2014. PMID 25551587.
• "Pepsinogen II can be a potential surrogate marker of morphological changes in corpus before and after H. pylori eradication. ". Biomed Res Int. 2014. PMID 25028655.
• "Serum Pepsinogen Levels Are Correlated With Age, Sex and the Level of Helicobacter pylori Infection in Healthy Individuals. ". Am J Med Sci. 2016. PMID 27865295.
• "Pepsinogen-II 100 bp ins/del gene polymorphism and its elevated circulating levels are associated with gastric cancer, particularly with Helicobacter pylori infection and intestinal metaplasia. ". Gastric Cancer. 2016. PMID 26486507.
• "Polymorphic rs9471643 and rs6458238 upregulate PGC transcription and protein expression in overdominant or dominant models.". Mol Carcinog. 2016. PMID 25857852.