PFN1

PFN1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1AWI, 1CF0, 1CJF, 1FIK, 1FIL, 1PFL, 2PAV, 2PBD, 3CHW, 4X1L, 4X1M, 4X25
Dynodwyr
Cyfenwau	PFN1, ALS18, Profilin 1
Dynodwyr allanol	OMIM: 176610 HomoloGene: 3684 GeneCards: PFN1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • actin monomer binding • GO:0001948, GO:0016582 protein binding • adenyl-nucleotide exchange factor activity • actin binding • proline-rich region binding • RNA binding • cadherin binding • signaling receptor binding • phosphatidylinositol-4,5-bisphosphate binding Cydrannau o'r gell • cytosol • blood microparticle • bilen • focal adhesion • cell cortex • extracellular exosome • Cytosgerbwd • cytoplasm • cnewyllyn cell • extracellular space • neuron projection • synapse • glutamatergic synapse Prosesau biolegol • positive regulation of actin filament polymerization • positive regulation of ATP-dependent activity • negative regulation of actin filament polymerization • positive regulation of ruffle assembly • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II • protein stabilization • positive regulation of epithelial cell migration • negative regulation of actin filament bundle assembly • neural tube closure • positive regulation of actin filament bundle assembly • negative regulation of stress fiber assembly • actin cytoskeleton organization • Wnt signaling pathway, planar cell polarity pathway • response to organic substance • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • positive regulation of viral transcription • positive regulation of DNA metabolic process • positive regulation of stress fiber assembly • cellular response to growth factor stimulus • regulation of actin filament polymerization • synapse maturation • modification of postsynaptic actin cytoskeleton Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	5216	n/a
Ensembl	ENSG00000108518	n/a
UniProt	P07737	n/a
RefSeq (mRNA)	NM_005022 NM_001375991	n/a
RefSeq (protein)	NP_005013 NP_001362920	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PFN1 yw PFN1 a elwir hefyd yn Profilin 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 17, band 17p13.2.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PFN1.

• ALS18

Llyfryddiaeth

• "Mutant Profilin1 transgenic mice recapitulate cardinal features of motor neuron disease. ". Hum Mol Genet. 2017. PMID 28040732.
• "Profilin1 biology and its mutation, actin(g) in disease. ". Cell Mol Life Sci. 2017. PMID 27669692.
• "ALS-causing profilin-1-mutant forms a non-native helical structure in membrane environments. ". Biochim Biophys Acta. 2017. PMID 28847504.
• "Human profilin 1 is a negative regulator of CTL mediated cell-killing and migration. ". Eur J Immunol. 2017. PMID 28688208.
• "Self-Assembly of Human Profilin-1 Detected by Carr-Purcell-Meiboom-Gill Nuclear Magnetic Resonance (CPMG NMR) Spectroscopy.". Biochemistry. 2017. PMID 28052669.