PFKFB3

PFKFB3
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2AXN, 2DWO, 2DWP, 2I1V, 3QPU, 3QPV, 3QPW, 4MA4, 5AJV, 5AJW, 5AJX, 5AJY, 5AJZ, 5AK0, 4D4K, 4D4M, 4D4L, 4D4J
Dynodwyr
Cyfenwau	PFKFB3, IPFK2, PFK2, iPFK-2, 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
Dynodwyr allanol	OMIM: 605319 HomoloGene: 88708 GeneCards: PFKFB3
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • transferase activity • nucleotide binding • fructose-2,6-bisphosphate 2-phosphatase activity • catalytic activity • hydrolase activity • ATP binding • kinase activity • 6-phosphofructo-2-kinase activity Cydrannau o'r gell • cytosol • nucleoplasm Prosesau biolegol • fructose metabolic process • metabolaeth • brain development • fructose 2,6-bisphosphate metabolic process • phosphorylation • GO:0098501, GO:0098502, GO:0006286 dephosphorylation • carbohydrate phosphorylation • positive regulation of glycolytic process Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	5209	n/a
Ensembl	ENSG00000170525	n/a
UniProt	Q16875 Q9BQU1	n/a
RefSeq (mRNA)	NM_001145443 NM_001282630 NM_001314063 NM_004566 NM_001323016 NM_001323017 NM_001363545	n/a
RefSeq (protein)	NP_001138915 NP_001269559 NP_001300992 NP_001309945 NP_001309946 NP_004557 NP_001350474	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PFKFB3 yw PFKFB3 a elwir hefyd yn 6-phosphofructo-2-kinase/ fructose-2,6-bisphosphatase a 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 10, band 10p15.1.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PFKFB3.

• PFK2
• IPFK2
• iPFK-2

Llyfryddiaeth

• "Reduced methylation of PFKFB3 in cancer cells shunts glucose towards the pentose phosphate pathway. ". Nat Commun. 2014. PMID 24633012.
• "Estradiol stimulates glucose metabolism via 6-phosphofructo-2-kinase (PFKFB3). ". J Biol Chem. 2014. PMID 24515104.
• "By inhibiting PFKFB3, aspirin overcomes sorafenib resistance in hepatocellular carcinoma. ". Int J Cancer. 2017. PMID 28857200.
• "PFKFB3 was overexpressed in gastric cancer patients and promoted the proliferation and migration of gastric cancer cells. ". Cancer Biomark. 2017. PMID 27983531.
• "PFKFB3 modulates glycolytic metabolism and alleviates endoplasmic reticulum stress in human osteoarthritis cartilage.". Clin Exp Pharmacol Physiol. 2016. PMID 26718307.