PEX5

PEX5
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1FCH, 2C0L, 2C0M, 2J9Q, 2W84, 3R9A, 4BXU, 4KXK, 4KYO
Dynodwyr
Cyfenwau	PEX5, peroxisomal biogenesis factor 5, RCDP5, PTS1R, PBD2B, PTS1-BP, PXR1, PBD2A
Dynodwyr allanol	OMIM: 600414 HomoloGene: 270 GeneCards: PEX5
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • protein C-terminus binding • small GTPase binding • protein N-terminus binding • peroxisome targeting sequence binding • enzyme binding • GO:0001948, GO:0016582 protein binding • peroxisome matrix targeting signal-1 binding Cydrannau o'r gell • cytoplasm • peroxisome • bilen • peroxisomal matrix • intracellular anatomical structure • Golgi apparatus • cytosol • peroxisomal membrane • GO:0009327 protein-containing complex Prosesau biolegol • negative regulation of protein homotetramerization • protein import into peroxisome membrane • protein import into peroxisome matrix, docking • protein tetramerization • protein transport • protein targeting to peroxisome • protein import into peroxisome matrix, translocation • protein import into peroxisome matrix • protein ubiquitination • GO:0015915 transport Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	5830	n/a
Ensembl	ENSG00000139197 ENSG00000288217	n/a
UniProt	P50542	n/a
RefSeq (mRNA)	NM_000319 NM_001131023 NM_001131024 NM_001131025 NM_001131026 NM_001300789 NM_001351124 NM_001351126 NM_001351127 NM_001351128 NM_001351130 NM_001351131 NM_001351132 NM_001351133 NM_001351134 NM_001351135 NM_001351136 NM_001351137 NM_001351138 NM_001351139 NM_001351140 NM_001374645 NM_001374646 NM_001374647 NM_001374648 NM_001374649	n/a
RefSeq (protein)	NP_000310 NP_001124495 NP_001124496 NP_001124497 NP_001124498 NP_001287718 NP_001338053 NP_001338055 NP_001338056 NP_001338057 NP_001338059 NP_001338060 NP_001338061 NP_001338062 NP_001338063 NP_001338064 NP_001338065 NP_001338066 NP_001338067 NP_001338068 NP_001338069	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PEX5 yw PEX5 a elwir hefyd yn Peroxisomal targeting signal 1 receptor a Peroxisomal biogenesis factor 5 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 12, band 12p13.31.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PEX5.

• PXR1
• PBD2A
• PBD2B
• PTS1R
• RCDP5
• PTS1-BP

Llyfryddiaeth

• "Ligand-induced compaction of the PEX5 receptor-binding cavity impacts protein import efficiency into peroxisomes. ". Traffic. 2015. PMID 25369882.
• "Distinct modes of ubiquitination of peroxisome-targeting signal type 1 (PTS1) receptor Pex5p regulate PTS1 protein import. ". J Biol Chem. 2014. PMID 24662292.
• "Functional variants inPXRare associated with colorectal cancer susceptibility in Chinese populations. ". Cancer Epidemiol. 2015. PMID 26547791.
• "A novel type of rhizomelic chondrodysplasia punctata, RCDP5, is caused by loss of the PEX5 long isoform. ". Hum Mol Genet. 2015. PMID 26220973.
• "Molecular recognition of PTS-1 cargo proteins by Pex5p: implications for protein mistargeting in primary hyperoxaluria.". Biomolecules. 2015. PMID 25689234.