PELI2

PELI2
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 3EGA, 3EGB
Dynodwyr
Cyfenwau	PELI2, pellino E3 ubiquitin protein ligase family member 2
Dynodwyr allanol	OMIM: 614798 HomoloGene: 41431 GeneCards: PELI2
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0001948, GO:0016582 protein binding • ubiquitin-ubiquitin ligase activity • protein serine/threonine kinase activity • transferase activity • GO:1904264, GO:1904822, GO:0090622, GO:0090302 ubiquitin protein ligase activity Cydrannau o'r gell • cytosol Prosesau biolegol • positive regulation of I-kappaB kinase/NF-kappaB signaling • positive regulation of protein phosphorylation • protein ubiquitination • positive regulation of MAPK cascade • protein polyubiquitination • protein phosphorylation • GO:0046730, GO:0046737, GO:0046738, GO:0046736 immune response • Toll signaling pathway • interleukin-1-mediated signaling pathway • regulation of Toll signaling pathway Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	57161	n/a
Ensembl	ENSG00000139946	n/a
UniProt	Q9HAT8	n/a
RefSeq (mRNA)	NM_021255	n/a
RefSeq (protein)	NP_067078	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PELI2 yw PELI2 a elwir hefyd yn Pellino E3 ubiquitin protein ligase family member 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 14, band 14q22.3.

Llyfryddiaeth

• "Characterization of Pellino2, a substrate of IRAK1 and IRAK4. ". FEBS Lett. 2003. PMID 12860405.
• "Cutting edge: mouse pellino-2 modulates IL-1 and lipopolysaccharide signaling. ". J Immunol. 2002. PMID 12370331.
• "Pellino 2 is critical for Toll-like receptor/interleukin-1 receptor (TLR/IL-1R)-mediated post-transcriptional control. ". J Biol Chem. 2012. PMID 22669975.
• "Pellino proteins contain a cryptic FHA domain that mediates interaction with phosphorylated IRAK1. ". Structure. 2008. PMID 19081057.
• "Pellino proteins are more than scaffold proteins in TLR/IL-1R signalling: a role as novel RING E3-ubiquitin-ligases.". FEBS Lett. 2006. PMID 16884718.