PDXK

PDXK
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2AJP, 2F7K, 2YXT, 2YXU, 3FHX, 3FHY, 3KEU, 4EN4, 4EOH
Dynodwyr
Cyfenwau	PDXK, C21orf124, C21orf97, HEL-S-1a, PKH, PNK, PRED79, pyridoxal (pyridoxine, vitamin B6) kinase, pyridoxal kinase, HMSN6C
Dynodwyr allanol	OMIM: 179020 HomoloGene: 2731 GeneCards: PDXK
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • transferase activity • nucleotide binding • protein homodimerization activity • pyridoxal kinase activity • zinc ion binding • potassium ion binding • sodium ion binding • metal ion binding • kinase activity • lithium ion binding • pyridoxal phosphate binding • ATP binding • magnesium ion binding Cydrannau o'r gell • cytosol • extracellular exosome • cnewyllyn cell • extracellular region • cytoplasm • secretory granule lumen • specific granule lumen • nucleoplasm Prosesau biolegol • pyridoxal phosphate biosynthetic process • phosphorylation • pyridoxal 5'-phosphate salvage • cell population proliferation • neutrophil degranulation • vitamin B6 metabolic process Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	8566	n/a
Ensembl	ENSG00000160209	n/a
UniProt	O00764	n/a
RefSeq (mRNA)	NM_003681 NM_021941 NM_001331030	n/a
RefSeq (protein)	NP_001317959 NP_003672	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PDXK yw PDXK a elwir hefyd yn Pyridoxal kinase (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 21, band 21q22.3.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PDXK.

• PKH
• PNK
• PRED79
• C21orf97
• HEL-S-1a
• C21orf124

Llyfryddiaeth

• "The genetic basis of human erythrocyte pyridoxal kinase activity variation. ". Haematologica. 2006. PMID 16704963.
• "Expression of a novel pyridoxal kinase mRNA splice variant, PKH-T, in human testis. ". Asian J Androl. 2004. PMID 15154080.
• "Epilepsy as a pyridoxine-dependent condition: quantified urinary biomarkers for status evaluation and monitoring antiepileptic treatment. ". Med Hypotheses. 2012. PMID 22647618.
• "The PDXK rs2010795 variant is not associated with Parkinson disease in Italy. ". Ann Neurol. 2010. PMID 20373357.
• "Kinetic and structural studies of the role of the active site residue Asp235 of human pyridoxal kinase.". Biochem Biophys Res Commun. 2009. PMID 19351586.