PDK4

PDK4
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2E0A, 2ZDX, 2ZDY, 2ZKJ, 3D2R
Dynodwyr
Cyfenwau	PDK4, pyruvate dehydrogenase kinase 4
Dynodwyr allanol	OMIM: 602527 HomoloGene: 129720 GeneCards: PDK4
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • transferase activity • nucleotide binding • protein kinase activity • kinase activity • ATP binding • pyruvate dehydrogenase (acetyl-transferring) kinase activity Cydrannau o'r gell • mitochondrial matrix • mitocondria Prosesau biolegol • GO:1901047 insulin receptor signaling pathway • glucose homeostasis • regulation of fatty acid oxidation • phosphorylation • cellular response to starvation • regulation of acetyl-CoA biosynthetic process from pyruvate • regulation of fatty acid biosynthetic process • reactive oxygen species metabolic process • regulation of cellular ketone metabolic process • regulation of glucose metabolic process • cellular response to fatty acid • glucose metabolic process • response to starvation • regulation of bone resorption • negative regulation of anoikis • regulation of pH • protein phosphorylation • carbohydrate metabolic process Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	5166	n/a
Ensembl	ENSG00000004799	n/a
UniProt	Q16654	n/a
RefSeq (mRNA)	NM_002612	n/a
RefSeq (protein)	NP_002603	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PDK4 yw PDK4 a elwir hefyd yn Pyruvate dehydrogenase kinase 4 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 7, band 7q21.3.

Llyfryddiaeth

• "Increased pyruvate dehydrogenase kinase expression in cultured myotubes from obese and diabetic individuals. ". Eur J Nutr. 2015. PMID 25311062.
• "Association of pyruvate dehydrogenase kinase 4 gene polymorphisms with type 2 diabetes and metabolic syndrome. ". Diabetes Res Clin Pract. 2012. PMID 22019269.
• "Oncogenic role of PDK4 in human colon cancer cells. ". Br J Cancer. 2017. PMID 28208156.
• "Increased Pyruvate Dehydrogenase Kinase 4 Expression in Lung Pericytes Is Associated with Reduced Endothelial-Pericyte Interactions and Small Vessel Loss in Pulmonary Arterial Hypertension. ". Am J Pathol. 2016. PMID 27456128.
• "Pyruvate dehydrogenase kinase 4 (PDK4) could be involved in a regulatory role in apoptosis and a link between apoptosis and insulin resistance.". Exp Mol Pathol. 2015. PMID 25794976.