PDK3

PDK3
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1Y8N, 1Y8O, 1Y8P, 2PNR, 2Q8I
Dynodwyr
Cyfenwau	PDK3, CMTX6, GS1-358P8.4, pyruvate dehydrogenase kinase 3
Dynodwyr allanol	OMIM: 300906 HomoloGene: 55897 GeneCards: PDK3
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • transferase activity • nucleotide binding • protein kinase activity • kinase activity • protein serine/threonine kinase activity • GO:0001948, GO:0016582 protein binding • ATP binding • pyruvate dehydrogenase (acetyl-transferring) kinase activity Cydrannau o'r gell • mitochondrial matrix • nucleolus • mitocondria Prosesau biolegol • phosphorylation • peroxisome proliferator activated receptor signaling pathway • hypoxia-inducible factor-1alpha signaling pathway • GO:1904489 regulation of reactive oxygen species metabolic process • regulation of acetyl-CoA biosynthetic process from pyruvate • regulation of glucose metabolic process • cellular response to fatty acid • GO:0035404 peptidyl-serine phosphorylation • glucose metabolic process • cellular response to glucose stimulus • carbohydrate metabolic process Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	5165	n/a
Ensembl	ENSG00000067992	n/a
UniProt	Q15120	n/a
RefSeq (mRNA)	NM_005391 NM_001142386	n/a
RefSeq (protein)	NP_001135858 NP_005382	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PDK3 yw PDK3 a elwir hefyd yn Pyruvate dehydrogenase kinase 3 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom X dynol, band Xp22.11.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PDK3.

• CMTX6
• GS1-358P8.4

Llyfryddiaeth

• "Structural determinants for cross-talk between pyruvate dehydrogenase kinase 3 and lipoyl domain 2 of the human pyruvate dehydrogenase complex. ". J Biol Chem. 2006. PMID 16849321.
• "Therapeutic potential of the mammalian pyruvate dehydrogenase kinases in the prevention of hyperglycaemia. ". Curr Drug Targets Immune Endocr Metabol Disord. 2002. PMID 12476789.
• "X-linked Charcot-Marie-Tooth disease type 6 (CMTX6) patients with a p.R158H mutation in the pyruvate dehydrogenase kinase isoenzyme 3 gene. ". J Peripher Nerv Syst. 2016. PMID 26801680.
• "A new locus for X-linked dominant Charcot-Marie-Tooth disease (CMTX6) is caused by mutations in the pyruvate dehydrogenase kinase isoenzyme 3 (PDK3) gene. ". Hum Mol Genet. 2013. PMID 23297365.
• "Crystal structure of an asymmetric complex of pyruvate dehydrogenase kinase 3 with lipoyl domain 2 and its biological implications.". J Mol Biol. 2007. PMID 17532006.