PDK2

PDK2
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2BTZ, 2BU2, 2BU5, 2BU6, 2BU7, 2BU8, 4MP2, 4MP7, 4MPC, 4MPE, 4MPN, 4V25, 4V26
Dynodwyr
Cyfenwau	PDK2, PDHK2, PDKII, pyruvate dehydrogenase kinase 2
Dynodwyr allanol	OMIM: 602525 HomoloGene: 68265 GeneCards: PDK2
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • transferase activity • nucleotide binding • protein kinase activity • protein homodimerization activity • kinase activity • ATP binding • pyruvate dehydrogenase (acetyl-transferring) kinase activity Cydrannau o'r gell • nucleoplasm • mitochondrial matrix • mitocondria • mitochondrial pyruvate dehydrogenase complex • cytosol Prosesau biolegol • phosphorylation • GO:0072353 cellular response to reactive oxygen species • intrinsic apoptotic signaling pathway by p53 class mediator • glucose metabolic process • regulation of acetyl-CoA biosynthetic process from pyruvate • cellular response to nutrient • GO:1901047 insulin receptor signaling pathway • regulation of cellular ketone metabolic process • regulation of glucose metabolic process • glucose homeostasis • regulation of pH • protein phosphorylation • regulation of gluconeogenesis • carbohydrate metabolic process • regulation of calcium-mediated signaling Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	5164	n/a
Ensembl	ENSG00000005882	n/a
UniProt	Q15119	n/a
RefSeq (mRNA)	NM_002611 NM_001199898 NM_001199899 NM_001199900	n/a
RefSeq (protein)	NP_001186827 NP_001186828 NP_001186829 NP_002602	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PDK2 yw PDK2 a elwir hefyd yn [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial a Pyruvate dehydrogenase kinase 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 17, band 17q21.33.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PDK2.

• PDHK2
• PDKII

Llyfryddiaeth

• "Ligand-induced effects on pyruvate dehydrogenase kinase isoform 2. ". J Biol Chem. 2006. PMID 16517984.
• "Role of protein-protein interactions in the regulation of pyruvate dehydrogenase kinase activity. ". Biochem J. 2005. PMID 15504108.
• "Activation of mitochondrial oxidation by PDK2 inhibition reverses cisplatin resistance in head and neck cancer. ". Cancer Lett. 2016. PMID 26607904.
• "Specific ion influences on self-association of pyruvate dehydrogenase kinase isoform 2 (PDHK2), binding of PDHK2 to the L2 lipoyl domain, and effects of the lipoyl group-binding site inhibitor, Nov3r. ". Biochemistry. 2008. PMID 18220415.
• "Critical role of specific ions for ligand-induced changes regulating pyruvate dehydrogenase kinase isoform 2.". Biochemistry. 2008. PMID 18220414.