PDGFB

PDGFB
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1PDG, 3MJG, 4HQU, 4HQX, 4QCI
Dynodwyr
Cyfenwau	PDGFB, IBGC5, PDGF-2, PDGF2, SIS, SSV, c-sis, platelet derived growth factor subunit B
Dynodwyr allanol	OMIM: 190040 HomoloGene: 74303 GeneCards: PDGFB
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • protein homodimerization activity • protein heterodimerization activity • chemoattractant activity • platelet-derived growth factor receptor binding • platelet-derived growth factor binding • superoxide-generating NADPH oxidase activator activity • growth factor activity • identical protein binding • collagen binding • GO:0001948, GO:0016582 protein binding • phosphatidylinositol-4,5-bisphosphate 3-kinase activity Cydrannau o'r gell • platelet alpha granule lumen • cytoplasm • extracellular region • Golgi membrane • basolateral plasma membrane • cell surface • endoplasmic reticulum lumen • bilen • GO:0005578 extracellular matrix • extracellular space • Golgi lumen • collagen-containing extracellular matrix Prosesau biolegol • activation of protein kinase B activity • positive regulation of DNA biosynthetic process • positive regulation of chemotaxis • cellular response to growth factor stimulus • positive regulation of protein tyrosine kinase activity • peptidyl-tyrosine phosphorylation • positive regulation of cell division • heart development • positive regulation of glomerular filtration • positive regulation of mitotic nuclear division • positive regulation of MAP kinase activity • positive regulation of metanephric mesenchymal cell migration • positive regulation of hyaluronan biosynthetic process • MAPK cascade • protein phosphorylation • positive regulation of glomerular mesangial cell proliferation • cellular response to mycophenolic acid • positive regulation of fibroblast proliferation • activation of protein kinase activity • multicellular organism development • positive regulation of protein autophosphorylation • positive regulation of reactive oxygen species metabolic process • reactive oxygen species metabolic process • GO:0045996 negative regulation of transcription, DNA-templated • protein kinase C signaling • metanephric glomerular mesangial cell development • negative regulation of phosphatidylinositol biosynthetic process • response to wounding • positive regulation of phosphatidylinositol 3-kinase activity • cell chemotaxis • positive regulation of ERK1 and ERK2 cascade • platelet degranulation • positive regulation of cell population proliferation • positive regulation of DNA replication • GO:1901313 positive regulation of gene expression • embryonic placenta development • paracrine signaling • monocyte chemotaxis • positive regulation of endothelial cell proliferation • positive regulation of phosphatidylinositol 3-kinase signaling • positive regulation of calcium ion import • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • GO:0035404 peptidyl-serine phosphorylation • positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway • positive regulation of blood vessel endothelial cell migration • hemopoiesis • positive regulation of cell migration • positive regulation of peptidyl-tyrosine phosphorylation • extracellular matrix organization • negative regulation of protein binding • positive regulation of MAPK cascade • positive regulation of cyclin-dependent protein serine/threonine kinase activity • negative regulation of platelet activation • phosphatidylinositol phosphate biosynthetic process • positive regulation of vascular associated smooth muscle cell migration • positive chemotaxis • negative regulation of vascular associated smooth muscle cell differentiation • interleukin-18-mediated signaling pathway • positive regulation of pri-miRNA transcription by RNA polymerase II • negative regulation of pri-miRNA transcription by RNA polymerase II • negative regulation of gene expression • positive regulation of smooth muscle cell migration • positive regulation of smooth muscle cell proliferation • positive regulation of vascular associated smooth muscle cell dedifferentiation • platelet-derived growth factor receptor signaling pathway • positive regulation of vascular associated smooth muscle cell proliferation • negative regulation of platelet-derived growth factor receptor-beta signaling pathway • regulation of signaling receptor activity • positive regulation of protein kinase B signaling Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	5155	n/a
Ensembl	ENSG00000100311	n/a
UniProt	P01127	n/a
RefSeq (mRNA)	NM_033016 NM_002608	n/a
RefSeq (protein)	NP_002599 NP_148937	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PDGFB yw PDGFB a elwir hefyd yn Platelet derived growth factor subunit B (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 22, band 22q13.1.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PDGFB.

• SIS
• SSV
• IBGC5
• PDGF2
• c-sis
• PDGF-2

Llyfryddiaeth

• "Platelet-derived growth factor regulates the proliferation and differentiation of human melanocytes in a differentiation-stage-specific manner. ". J Dermatol Sci. 2016. PMID 27289338.
• "The platelet derived growth factor-B polymorphism is associated with risk of severe fever with thrombocytopenia syndrome in Chinese individuals. ". Oncotarget. 2016. PMID 27147565.
• "Platelet-Derived Growth Factor BB Influences Muscle Regeneration in Duchenne Muscle Dystrophy. ". Am J Pathol. 2017. PMID 28618254.
• "Platelet Derived Growth Factor BB: A "Must-have" Therapeutic Target "Redivivus" in Ovarian Cancer. ". Cancer Genomics Proteomics. 2016. PMID 27807074.
• "PDGFB, a new candidate plasma biomarker for venous thromboembolism: results from the VEREMA affinity proteomics study.". Blood. 2016. PMID 27742707.