PDE9A

PDE9A
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2HD1, 2YY2, 3DY8, 3DYL, 3DYN, 3DYQ, 3DYS, 3JSI, 3JSW, 3K3E, 3K3H, 3N3Z, 3QI3, 3QI4, 4E90, 4G2J, 4G2L, 4GH6, 4Y86, 4Y87, 4Y8C
Dynodwyr
Cyfenwau	PDE9A, HSPDE9A2, phosphodiesterase 9A
Dynodwyr allanol	OMIM: 602973 HomoloGene: 113565 GeneCards: PDE9A
EC number	3.1.4.35
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • 3',5'-cyclic-nucleotide phosphodiesterase activity • metal ion binding • GO:0001948, GO:0016582 protein binding • phosphoric diester hydrolase activity • hydrolase activity • 3',5'-cyclic-GMP phosphodiesterase activity Cydrannau o'r gell • cytoplasm • cytosol • perikaryon • Golgi apparatus • cell projection • bilen • Cellbilen • ruffle membrane • Reticwlwm endoplasmig • perinuclear region of cytoplasm • sarcolemma Prosesau biolegol • cGMP metabolic process • cGMP-mediated signaling • positive regulation of cardiac muscle hypertrophy • cGMP catabolic process • GO:0072468 signal transduction Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	5152	n/a
Ensembl	ENSG00000160191	n/a
UniProt	O76083	n/a
RefSeq (mRNA)	NM_001001567 NM_001001568 NM_001001569 NM_001001570 NM_001001571 NM_001001572 NM_001001573 NM_001001574 NM_001001575 NM_001001576 NM_001001577 NM_001001578 NM_001001579 NM_001001580 NM_001001581 NM_001001582 NM_001001583 NM_001001584 NM_001001585 NM_002606 NM_001315533	n/a
RefSeq (protein)	NP_001001567 NP_001001568 NP_001001569 NP_001001570 NP_001001571 NP_001001572 NP_001001573 NP_001001574 NP_001001575 NP_001001576 NP_001001577 NP_001001578 NP_001001579 NP_001001580 NP_001001581 NP_001001582 NP_001001583 NP_001001584 NP_001001585 NP_001302462 NP_002597	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PDE9A yw PDE9A a elwir hefyd yn Phosphodiesterase 9A (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 21, band 21q22.3.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PDE9A.

• HSPDE9A2

Llyfryddiaeth

• "Crystal structure of phosphodiesterase 9 shows orientation variation of inhibitor 3-isobutyl-1-methylxanthine binding. ". Proc Natl Acad Sci U S A. 2004. PMID 15210993.
• "Identification and characterization of a new human type 9 cGMP-specific phosphodiesterase splice variant (PDE9A5). Differential tissue distribution and subcellular localization of PDE9A variants. ". Gene. 2003. PMID 14527714.
• "Phosphodiesterase 9A regulates central cGMP and modulates responses to cholinergic and monoaminergic perturbation in vivo. ". J Pharmacol Exp Ther. 2012. PMID 22328573.
• "Inhibition of phosphodiesterase 9A reduces cytokine-stimulated in vitro adhesion of neutrophils from sickle cell anemia individuals. ". Inflamm Res. 2011. PMID 21336703.
• "Specific use of start codons and cellular localization of splice variants of human phosphodiesterase 9A gene.". BMC Mol Biol. 2006. PMID 17090334.