PDE8A

PDE8A
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 3ECM, 3ECN
Dynodwyr
Cyfenwau	PDE8A, HsT19550, phosphodiesterase 8A
Dynodwyr allanol	OMIM: 602972 HomoloGene: 1957 GeneCards: PDE8A
EC number	3.1.4.53
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • phosphoric diester hydrolase activity • hydrolase activity • 3',5'-cyclic-nucleotide phosphodiesterase activity • metal ion binding • 3',5'-cyclic-AMP phosphodiesterase activity • kinase binding • 3',5'-cyclic-GMP phosphodiesterase activity Cydrannau o'r gell • cytosol • extracellular exosome Prosesau biolegol • cyclic nucleotide metabolic process • cAMP catabolic process • GO:0009373 regulation of transcription, DNA-templated • GO:0072468 signal transduction • positive regulation of protein phosphorylation • negative regulation of cell death • positive regulation of ERK1 and ERK2 cascade • cellular response to epidermal growth factor stimulus • negative regulation of hydrogen peroxide-induced cell death • G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	5151	n/a
Ensembl	ENSG00000073417	n/a
UniProt	O60658	n/a
RefSeq (mRNA)	NM_001243137 NM_002605 NM_173454 NM_173455 NM_173456 NM_173457	n/a
RefSeq (protein)	NP_001230066 NP_002596 NP_775656	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PDE8A yw PDE8A a elwir hefyd yn Phosphodiesterase 8A (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 15, band 15q25.3.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PDE8A.

• HsT19550

Llyfryddiaeth

• "Polymorphism in HIV-1 dependency factor PDE8A affects mRNA level and HIV-1 replication in primary macrophages. ". Virology. 2011. PMID 21920574.
• "PDE8A genetic variation, polycystic ovary syndrome and androgen levels in women. ". Mol Hum Reprod. 2009. PMID 19482904.
• "Phosphodiesterase 8a supports HIV-1 replication in macrophages at the level of reverse transcription. ". PLoS One. 2014. PMID 25295610.
• "Active site coupling in PDE:PKA complexes promotes resetting of mammalian cAMP signaling. ". Biophys J. 2014. PMID 25229150.
• "Cyclic AMP-specific phosphodiesterase, PDE8A1, is activated by protein kinase A-mediated phosphorylation.". FEBS Lett. 2012. PMID 22673573.