PDE4D

PDE4D
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1MKD, 1OYN, 1PTW, 1Q9M, 1TB7, 1TBB, 1XOM, 1XON, 1XOQ, 1XOR, 1Y2B, 1Y2C, 1Y2D, 1Y2E, 1Y2K, 1ZKN, 2FM0, 2FM5, 2PW3, 2QYN, 3G4G, 3G4I, 3G4K, 3G4L, 3G58, 3IAD, 3IAK, 3K4S, 3SL3, 3SL4, 3SL5, 3SL6, 3SL8, 3V9B, 4OGB, 4W1O, 4WCU
Dynodwyr
Cyfenwau	PDE4D, ACRDYS2, DPDE3, HSPDE43, PDE4DN2, STRK1, phosphodiesterase 4D
Dynodwyr allanol	OMIM: 600129 HomoloGene: 129755 GeneCards: PDE4D
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • ATPase binding • scaffold protein binding • cAMP binding • metal ion binding • beta-2 adrenergic receptor binding • GO:0001948, GO:0016582 protein binding • phosphoric diester hydrolase activity • enzyme binding • hydrolase activity • ubiquitin protein ligase binding • transmembrane transporter binding • 3',5'-cyclic-AMP phosphodiesterase activity • 3',5'-cyclic-nucleotide phosphodiesterase activity Cydrannau o'r gell • cytoplasm • cytosol • centrosome • microtubule organizing center • apical plasma membrane • Cytosgerbwd • bilen • calcium channel complex • voltage-gated calcium channel complex • Cellbilen • nuclear membrane Prosesau biolegol • establishment of endothelial barrier • smooth muscle contraction • positive regulation of interleukin-5 production • multicellular organism growth • GO:0010260 heneiddio • regulation of signaling receptor activity • positive regulation of interferon-gamma production • neutrophil chemotaxis • positive regulation of interleukin-2 production • regulation of cell communication by electrical coupling involved in cardiac conduction • adrenergic receptor signaling pathway • cellular response to lipopolysaccharide • T cell receptor signaling pathway • adenylate cyclase-activating adrenergic receptor signaling pathway involved in positive regulation of heart rate • cAMP-mediated signaling • cellular response to cAMP • GO:0072468 signal transduction • leukocyte migration • negative regulation of relaxation of cardiac muscle • regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum • negative regulation of heart contraction • regulation of heart rate • regulation of ryanodine-sensitive calcium-release channel activity • cAMP catabolic process • cellular response to epinephrine stimulus • regulation of cardiac muscle cell contraction • negative regulation of peptidyl-serine phosphorylation • G protein-coupled receptor signaling pathway • negative regulation of cAMP-mediated signaling Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	5144	n/a
Ensembl	ENSG00000113448	n/a
UniProt	Q08499	n/a
RefSeq (mRNA)	NM_001104631 NM_001165899 NM_001197218 NM_001197219 NM_001197220 NM_001197221 NM_001197222 NM_001197223 NM_006203 NM_001349241 NM_001349242 NM_001349243 NM_001364599 NM_001364600 NM_001364601 NM_001364602 NM_001364603 NM_001364604	n/a
RefSeq (protein)	NP_001098101 NP_001159371 NP_001184147 NP_001184148 NP_001184149 NP_001184150 NP_001184151 NP_001184152 NP_006194 NP_001336170 NP_001336171 NP_001336172 NP_001351528 NP_001351529 NP_001351530 NP_001351531 NP_001351532 NP_001351533	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PDE4D yw PDE4D a elwir hefyd yn Phosphodiesterase 4D a cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 5, band 5q11.2-q12.1.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PDE4D.

• DPDE3
• PDE43
• STRK1
• ACRDYS2
• HSPDE4D
• PDE4DN2

Llyfryddiaeth

• "Phosphodiesterase 4D gene polymorphisms in sudden sensorineural hearing loss. ". Eur Arch Otorhinolaryngol. 2016. PMID 26521189.
• " Investigation of single nucleotide polymorphisms in phosphodiesterase 4D gene in Mongol and Han patients with ischemic stroke in Inner Mongolia. ". Genet Mol Res. 2015. PMID 26345966.
• "Impact of the PDE4D gene polymorphism and additional SNP-SNP and gene-smoking interaction on ischemic stroke risk in Chinese Han population. ". Neurol Res. 2017. PMID 28191858.
• "No Association Between SNP56 in PDE4D Gene and Susceptibility to Ischemic Stroke: A Meta-Analysis of 15 Studies. ". Med Sci Monit. 2016. PMID 27759001.
• "Phosphodiesterase4D (PDE4D)--A risk factor for atrial fibrillation and stroke?". J Neurol Sci. 2015. PMID 26671126.