PDE2A

PDE2A
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1Z1L, 3IBJ, 3ITM, 3ITU, 4C1I, 4D08, 4D09, 4HTX, 4HTZ, 4JIB
Dynodwyr
Cyfenwau	PDE2A, CGS-PDE, PDE2A1, PED2A4, cGSPDE, phosphodiesterase 2A, IDDPADS
Dynodwyr allanol	OMIM: 602658 HomoloGene: 1952 GeneCards: PDE2A
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • nucleotide binding • 3',5'-cyclic-nucleotide phosphodiesterase activity • calcium channel activity • cGMP binding • metal ion binding • cyclic-nucleotide phosphodiesterase activity • GO:0001948, GO:0016582 protein binding • phosphoric diester hydrolase activity • TPR domain binding • hydrolase activity • cGMP-stimulated cyclic-nucleotide phosphodiesterase activity • cAMP binding • protein homodimerization activity • 3',5'-cyclic-AMP phosphodiesterase activity • 3',5'-cyclic-GMP phosphodiesterase activity • identical protein binding • magnesium ion binding • zinc ion binding • phosphate ion binding Cydrannau o'r gell • cytoplasm • cytosol • Golgi apparatus • bilen • Cellbilen • Reticwlwm endoplasmig • mitocondria • perinuclear region of cytoplasm • presynaptic membrane • cnewyllyn cell • mitochondrial outer membrane • mitochondrial inner membrane • mitochondrial matrix Prosesau biolegol • establishment of endothelial barrier • cellular response to transforming growth factor beta stimulus • positive regulation of inflammatory response • cellular response to cGMP • GO:1901227 negative regulation of transcription by RNA polymerase II • monocyte differentiation • cGMP-mediated signaling • cellular response to macrophage colony-stimulating factor stimulus • cellular response to mechanical stimulus • positive regulation of vascular permeability • cellular response to granulocyte macrophage colony-stimulating factor stimulus • cAMP-mediated signaling • GO:0072468 signal transduction • negative regulation of vascular permeability • cGMP catabolic process • cAMP catabolic process • calcium ion transmembrane transport • G protein-coupled receptor signaling pathway • negative regulation of cAMP-mediated signaling • cellular response to cAMP • cellular response to 2,3,7,8-tetrachlorodibenzodioxine • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • GO:1901313 positive regulation of gene expression • negative regulation of cGMP-mediated signaling • regulation of mitochondrion organization • heart valve development • ventricular septum development • aorta development Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	5138	n/a
Ensembl	ENSG00000186642	n/a
UniProt	O00408	n/a
RefSeq (mRNA)	NM_001143839 NM_001146209 NM_001243784 NM_002599	n/a
RefSeq (protein)	NP_001137311 NP_001139681 NP_001230713 NP_002590	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PDE2A yw PDE2A a elwir hefyd yn cGMP-dependent 3',5'-cyclic phosphodiesterase a Phosphodiesterase 2a (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 11, band 11q13.4.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PDE2A.

• PDE2A1
• PED2A4
• cGSPDE
• CGS-PDE

Llyfryddiaeth

• "Characterization of phosphodiesterase 2A in human malignant melanoma PMP cells. ". Oncol Rep. 2013. PMID 23381931.
• "Tumor necrosis factor-alpha-dependent expression of phosphodiesterase 2: role in endothelial hyperpermeability. ". Blood. 2005. PMID 15650061.
• "Role of phosphodiesterase 2 in growth and invasion of human malignant melanoma cells. ". Cell Signal. 2014. PMID 24705027.
• "X-ray crystal structure of phosphodiesterase 2 in complex with a highly selective, nanomolar inhibitor reveals a binding-induced pocket important for selectivity. ". J Am Chem Soc. 2013. PMID 23899287.
• "Phosphodiesterase-2 is up-regulated in human failing hearts and blunts β-adrenergic responses in cardiomyocytes.". J Am Coll Cardiol. 2013. PMID 23810893.