PDE1B

PDE1B
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1TAZ, 4NPV, 4NPW, 5B25
Dynodwyr
Cyfenwau	PDE1B, PDE1B1, PDES1B, HEL-S-79p, phosphodiesterase 1B
Dynodwyr allanol	OMIM: 171891 HomoloGene: 37370 GeneCards: PDE1B
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • 3',5'-cyclic-nucleotide phosphodiesterase activity • metal ion binding • calmodulin binding • cyclic-nucleotide phosphodiesterase activity • calmodulin-dependent cyclic-nucleotide phosphodiesterase activity • GO:0001948, GO:0016582 protein binding • phosphoric diester hydrolase activity • hydrolase activity • calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity • 3',5'-cyclic-AMP phosphodiesterase activity • 3',5'-cyclic-GMP phosphodiesterase activity Cydrannau o'r gell • cytoplasm • neuronal cell body • cytosol Prosesau biolegol • visual learning • regulation of neurotransmitter levels • cAMP catabolic process • locomotory behavior • response to amphetamine • serotonin metabolic process • monocyte differentiation • regulation of dopamine metabolic process • cellular response to macrophage colony-stimulating factor stimulus • cGMP catabolic process • cellular response to granulocyte macrophage colony-stimulating factor stimulus • GO:0097285 apoptotic process • GO:0072468 signal transduction • G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	5153	n/a
Ensembl	ENSG00000123360	n/a
UniProt	Q01064	n/a
RefSeq (mRNA)	NM_000924 NM_001165975 NM_001288768 NM_001288769 NM_001315534 NM_001315535	n/a
RefSeq (protein)	NP_000915 NP_001159447 NP_001275697 NP_001275698 NP_001302463 NP_001302464	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PDE1B yw PDE1B a elwir hefyd yn Phosphodiesterase 1B (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 12, band 12q13.2.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PDE1B.

• PDE1B1
• PDES1B
• HEL-S-79p

Llyfryddiaeth

• "Selective up-regulation of PDE1B2 upon monocyte-to-macrophage differentiation. ". Proc Natl Acad Sci U S A. 2005. PMID 15625104.
• "Identification and characterisation of a human calmodulin-stimulated phosphodiesterase PDE1B1. ". Cell Signal. 1997. PMID 9419816.
• "Phosphodiesterases in neurodegenerative disorders. ". IUBMB Life. 2012. PMID 23129425.
• "Quantitative comparison of phosphodiesterase mRNA distribution in human brain and peripheral tissues. ". Neuropharmacology. 2010. PMID 20493887.
• "PDE1B2 regulates cGMP and a subset of the phenotypic characteristics acquired upon macrophage differentiation from a monocyte.". Proc Natl Acad Sci U S A. 2006. PMID 16407168.