PDCD10

PDCD10
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 3AJM, 3L8I, 3L8J, 3RQE, 3RQF, 3RQG, 3W8H, 3W8I, 4GEH, 4TVQ
Dynodwyr
Cyfenwau	PDCD10, CCM3, TFAR15, programmed cell death 10
Dynodwyr allanol	OMIM: 609118 HomoloGene: 10505 GeneCards: PDCD10
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • protein homodimerization activity • protein N-terminus binding • GO:0001948, GO:0016582 protein binding • protein kinase binding Cydrannau o'r gell • cytoplasm • cytosol • Golgi apparatus • bilen • Golgi membrane • Cellbilen • extracellular exosome Prosesau biolegol • intrinsic apoptotic signaling pathway in response to hydrogen peroxide • positive regulation of MAP kinase activity • positive regulation of cell migration • protein stabilization • negative regulation of apoptotic process • negative regulation of gene expression • establishment of Golgi localization • stress fiber assembly • positive regulation of peptidyl-serine phosphorylation • positive regulation of protein serine/threonine kinase activity • Golgi reassembly • negative regulation of cell migration involved in sprouting angiogenesis • GO:1901313 positive regulation of gene expression • angiogenesis • positive regulation of cell population proliferation • negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis • regulation of Rho protein signal transduction • response to hydrogen peroxide • wound healing, spreading of cells • positive regulation of Notch signaling pathway • positive regulation of stress-activated MAPK cascade • GO:0097285 apoptotic process • positive regulation of intracellular protein transport • cellular response to leukemia inhibitory factor Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	11235	n/a
Ensembl	ENSG00000114209	n/a
UniProt	Q9BUL8	n/a
RefSeq (mRNA)	NM_007217 NM_145859 NM_145860	n/a
RefSeq (protein)	NP_009148 NP_665858 NP_665859	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PDCD10 yw PDCD10 a elwir hefyd yn Programmed cell death 10, isoform CRA_b a Programmed cell death 10 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 3, band 3q26.1.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PDCD10.

• CCM3
• TFAR15

Llyfryddiaeth

• "Detection of Novel Mutation in Ccm3 Causes Familial Cerebral Cavernous Malformations. ". J Mol Neurosci. 2015. PMID 26115622.
• "The cerebral cavernous malformation 3 gene is necessary for senescence induction. ". Aging Cell. 2015. PMID 25655101.
• "Downregulation of programmed cell death 10 is associated with tumor cell proliferation, hyperangiogenesis and peritumoral edema in human glioblastoma. ". BMC Cancer. 2015. PMID 26490252.
• "Loss of endothelial programmed cell death 10 activates glioblastoma cells and promotes tumor growth. ". Neuro Oncol. 2016. PMID 26254477.
• "Cerebral cavernous malformations associated to meningioma: High penetrance in a novel family mutated in the PDCD10 gene.". Neuroradiol J. 2015. PMID 26246098.