PDCD1

PDCD1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2M2D, 3RRQ, 4ZQK
Dynodwyr
Cyfenwau	PDCD1, CD279, PD-1, PD1, SLEB2, hPD-1, hPD-l, hSLE1, Programmed cell death 1
Dynodwyr allanol	OMIM: 600244 HomoloGene: 3681 GeneCards: PDCD1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0001948, GO:0016582 protein binding • signal transducer activity Cydrannau o'r gell • integral component of membrane • Cellbilen • bilen • external side of plasma membrane Prosesau biolegol • positive regulation of apoptotic process • multicellular organism development • T cell costimulation • negative regulation of apoptotic process • positive regulation of T cell apoptotic process • humoral immune response • negative regulation of tolerance induction • immune system process • GO:0097285 apoptotic process • GO:0072468 signal transduction Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	5133	n/a
Ensembl	ENSG00000188389 ENSG00000276977	n/a
UniProt	Q15116	n/a
RefSeq (mRNA)	NM_005018	n/a
RefSeq (protein)	NP_005009	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PDCD1 yw PDCD1 a elwir hefyd yn Programmed cell death 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 2, band 2q37.3.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PDCD1.

• PD1
• PD-1
• CD279
• SLEB2
• hPD-1
• hPD-l
• hSLE1

Llyfryddiaeth

• "Programmed cell death-1, PD-1, is dysregulated in T cells from children with new onset type 1 diabetes. ". PLoS One. 2017. PMID 28877189.
• "Association of a PDCD1 Polymorphism With Sympathetic Ophthalmia in Han Chinese. ". Invest Ophthalmol Vis Sci. 2017. PMID 28846771.
• "Cutting Edge: A Critical Role of Lesional T Follicular Helper Cells in the Pathogenesis of IgG4-Related Disease. ". J Immunol. 2017. PMID 28916523.
• "PD-1 Status in CD8+ T Cells Associates with Survival and Anti-PD-1 Therapeutic Outcomes in Head and Neck Cancer. ". Cancer Res. 2017. PMID 28904066.
• "Increased Expression of Programmed Cell Death-1 in Regulatory T Cells of Patients with Severe Sepsis and Septic Shock: An Observational Clinical Study.". Scand J Immunol. 2017. PMID 28888058.