PCGF2

PCGF2
Dynodwyr
Cyfenwau	PCGF2, MEL-18, RNF110, ZNF144, polycomb group ring finger 2, TPFS
Dynodwyr allanol	OMIM: 600346 HomoloGene: 5174 GeneCards: PCGF2
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • metal ion binding • chromatin binding • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • DNA binding • GO:0001948, GO:0016582 protein binding • promoter-specific chromatin binding Cydrannau o'r gell • nucleoplasm • cnewyllyn cell • sex chromatin • nuclear body • PcG protein complex • PRC1 complex Prosesau biolegol • anterior/posterior pattern specification • transcription, DNA-templated • negative regulation of apoptotic signaling pathway • embryonic skeletal system morphogenesis • cellular response to hydrogen peroxide • histone acetylation • in utero embryonic development • GO:0009373 regulation of transcription, DNA-templated • embryonic skeletal system development • GO:1901227 negative regulation of transcription by RNA polymerase II • histone H2A-K119 monoubiquitination • negative regulation of G0 to G1 transition Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	7703	n/a
Ensembl	ENSG00000277258 ENSG00000278644	n/a
UniProt	P35227	n/a
RefSeq (mRNA)	NM_007144 NM_001369614 NM_001369615	n/a
RefSeq (protein)	NP_009075 NP_001356543 NP_001356544	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PCGF2 yw PCGF2 a elwir hefyd yn Polycomb group ring finger 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 17, band 17q12.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PCGF2.

• MEL-18
• RNF110
• ZNF144

Llyfryddiaeth

• "Low expression of Mel-18 predicts poor prognosis in patients with breast cancer. ". Ann Oncol. 2010. PMID 20444850.
• "The novel tumor-suppressor Mel-18 in prostate cancer: its functional polymorphism, expression and clinical significance. ". Int J Cancer. 2009. PMID 19585577.
• "Expression and clinicopathological significance of Mel-18 mRNA in colorectal cancer. ". Tumour Biol. 2014. PMID 24964959.
• "Loss of the polycomb protein Mel-18 enhances the epithelial-mesenchymal transition by ZEB1 and ZEB2 expression through the downregulation of miR-205 in breast cancer. ". Oncogene. 2014. PMID 23474752.
• "Mel-18, a mammalian Polycomb gene, regulates angiogenic gene expression of endothelial cells.". Biochem Biophys Res Commun. 2010. PMID 20801102.