PCBP2

PCBP2
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2AXY, 2JZX, 2P2R, 2PQU, 2PY9
Dynodwyr
Cyfenwau	PCBP2, HNRNPE2, HNRPE2, hnRNP-E2, poly(rC) binding protein 2
Dynodwyr allanol	OMIM: 601210 HomoloGene: 74536 GeneCards: PCBP2
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • DNA binding • enzyme binding • nucleic acid binding • ubiquitin protein ligase binding • GO:0001948, GO:0016582 protein binding • RNA binding • C-rich single-stranded DNA binding Cydrannau o'r gell • extracellular exosome • bilen • focal adhesion • nucleoplasm • cytoplasm • cnewyllyn cell • cytosol • GO:0097483, GO:0097481 postsynaptic density Prosesau biolegol • mRNA splicing, via spliceosome • negative regulation of defense response to virus • proteasome-mediated ubiquitin-dependent protein catabolic process • defense response to virus • mRNA metabolic process • negative regulation of type I interferon production • immune system process • innate immune response • viral RNA genome replication • IRES-dependent viral translational initiation • RNA metabolic process Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	5094	n/a
Ensembl	ENSG00000197111	n/a
UniProt	Q15366	n/a
RefSeq (mRNA)	NM_031989 NM_001098620 NM_001128911 NM_001128912 NM_001128913 NM_001128914 NM_005016	n/a
RefSeq (protein)	NP_001092090 NP_001122383 NP_001122384 NP_001122385 NP_001122386 NP_005007 NP_114366	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PCBP2 yw PCBP2 a elwir hefyd yn Poly(rC)-binding protein 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 12, band 12q13.13.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PCBP2.

• HNRPE2
• HNRNPE2
• hnRNP-E2

Llyfryddiaeth

• "Inhibition of poliovirus-induced cleavage of cellular protein PCBP2 reduces the levels of viral RNA replication. ". J Virol. 2014. PMID 24371074.
• "Iron homeostasis regulates the activity of the microRNA pathway through poly(C)-binding protein 2. ". Cell Metab. 2012. PMID 22633452.
• "Heterogeneous ribonuclear protein E2 (hnRNP E2) is associated with TDP-43-immunoreactive neurites in Semantic Dementia but not with other TDP-43 pathological subtypes of Frontotemporal Lobar Degeneration. ". Acta Neuropathol Commun. 2017. PMID 28666471.
• "Overexpression of PCBP2 contributes to poor prognosis and enhanced cell growth in human hepatocellular carcinoma. ". Oncol Rep. 2016. PMID 27748915.
• "Poly (C)-binding protein 2 (PCBP2) promotes the progression of esophageal squamous cell carcinoma (ESCC) through regulating cellular proliferation and apoptosis.". Pathol Res Pract. 2016. PMID 27461833.