PCBP1

PCBP1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1WVN, 1ZTG, 3VKE
Dynodwyr
Cyfenwau	PCBP1, HEL-S-85, HNRPE1, HNRPX, hnRNP-E1, hnRNP-X, poly(rC) binding protein 1
Dynodwyr allanol	OMIM: 601209 HomoloGene: 68506 GeneCards: PCBP1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • DNA binding • GO:0001948, GO:0016582 protein binding • mRNA binding • RNA binding • nucleic acid binding • single-stranded DNA binding • sequence-specific single stranded DNA binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific • cadherin binding Cydrannau o'r gell • cytoplasm • extracellular exosome • bilen • cnewyllyn cell • nucleoplasm • cytosol • nuclear speck • cytoplasmic ribonucleoprotein granule Prosesau biolegol • mRNA splicing, via spliceosome • viral RNA genome replication • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • RNA metabolic process Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	5093	n/a
Ensembl	ENSG00000169564	n/a
UniProt	Q15365	n/a
RefSeq (mRNA)	NM_006196	n/a
RefSeq (protein)	NP_006187	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PCBP1 yw PCBP1 a elwir hefyd yn Poly(rC) binding protein 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 2, band 2p13.3.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PCBP1.

• HNRPX
• HNRPE1
• hnRNP-X
• HEL-S-85
• hnRNP-E1

Llyfryddiaeth

• "Expression of poly(C)-binding protein 1 (PCBP1) in NSCLC as a negative regulator of EMT and its clinical value. ". Int J Clin Exp Pathol. 2015. PMID 26261610.
• "The PCBP1 gene encoding poly(rC) binding protein I is recurrently mutated in Burkitt lymphoma. ". Genes Chromosomes Cancer. 2015. PMID 26173642.
• "Evidence Favoring a Positive Feedback Loop for Physiologic Auto Upregulation of hnRNP-E1 during Prolonged Folate Deficiency in Human Placental Cells. ". J Nutr. 2017. PMID 28250194.
• "Poly(C)-binding protein 1 mediates drug resistance in colorectal cancer. ". Oncotarget. 2017. PMID 28076324.
• "Downregulated Poly-C binding protein-1 is a novel predictor associated with poor prognosis in Acute Myeloid Leukemia.". Diagn Pathol. 2015. PMID 26293996.