PARP3

PARP3
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2EOC, 3C49, 3C4H, 3CE0, 3FHB, 4GV0, 4GV2, 4GV4, 4L6Z, 4L70, 4L7L, 4L7N, 4L7O, 4L7P, 4L7R, 4L7U
Dynodwyr
Cyfenwau	PARP3, ADPRT3, ADPRTL2, ADPRTL3, ARTD3, IRT1, PADPRT-3, poly(ADP-ribose) polymerase family member 3
Dynodwyr allanol	OMIM: 607726 HomoloGene: 4005 GeneCards: PARP3
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • transferase activity • glycosyltransferase activity • catalytic activity • NAD+ ADP-ribosyltransferase activity • DNA ligase (ATP) activity • protein ADP-ribosylase activity • GO:0001948, GO:0016582 protein binding • NAD DNA ADP-ribosyltransferase activity Cydrannau o'r gell • cytoplasm • site of double-strand break • centriole • Cytosgerbwd • cnewyllyn cell • microtubule organizing center • nucleolus • Cromosom Prosesau biolegol • protein localization to site of double-strand break • DNA ligation involved in DNA repair • lagging strand elongation • regulation of mitotic spindle organization • positive regulation of DNA ligation • telomere maintenance • double-strand break repair • protein ADP-ribosylation • GO:0100026 DNA repair • negative regulation of telomerase RNA reverse transcriptase activity • protein poly-ADP-ribosylation • DNA ADP-ribosylation • negative regulation of isotype switching • protein auto-ADP-ribosylation • protein mono-ADP-ribosylation • positive regulation of double-strand break repair via nonhomologous end joining • cellular response to DNA damage stimulus Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	10039	n/a
Ensembl	ENSG00000041880	n/a
UniProt	Q9Y6F1	n/a
RefSeq (mRNA)	NM_001003931 NM_001003935 NM_005485 NM_001370239 NM_001370240	n/a
RefSeq (protein)	NP_001003931 NP_005476 NP_001357168 NP_001357169	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PARP3 yw PARP3 a elwir hefyd yn Poly(ADP-ribose) polymerase family member 3 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 3, band 3p21.2.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PARP3.

• IRT1
• ARTD3
• ADPRT3
• ADPRTL2
• ADPRTL3
• PADPRT-3

Llyfryddiaeth

• "Nick Your DNA, Mark Your Chromatin. ". Mol Cell. 2016. PMID 27716488.
• "PARP3 interacts with FoxM1 to confer glioblastoma cell radioresistance. ". Tumour Biol. 2015. PMID 26040766.
• "Reversible mono-ADP-ribosylation of DNA breaks. ". FEBS J. 2017. PMID 29054115.
• "PARP3 affects the relative contribution of homologous recombination and nonhomologous end-joining pathways. ". Nucleic Acids Res. 2014. PMID 24598253.
• "PARP-3 associates with polycomb group bodies and with components of the DNA damage repair machinery.". J Cell Biochem. 2007. PMID 16924674.