PARP1

PARP1
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1UK0, 1UK1, 1WOK, 2COK, 2CR9, 2CS2, 2DMJ, 2JVN, 2L30, 2L31, 2RCW, 2RD6, 2RIQ, 3GJW, 3GN7, 3L3L, 3L3M, 3OD8, 3ODA, 3ODC, 3ODE, 4AV1, 4DQY, 4GV7, 4HHY, 4HHZ, 4L6S, 4OPX, 4OQA, 4OQB, 4PJT, 4UND, 4ZZZ, 5A00, 4R5W, 4R6E, 4UXB, 2N8A, 4XHU, 4RV6, 5HA9, 5DS3
Dynodwyr
Cyfenwau	PARP1, ADPRT, ADPRT 1, ADPRT1, ARTD1, PARP, PARP-1, PPOL, pADPRT-1, poly(ADP-ribose) polymerase 1, Poly-PARP, PARS
Dynodwyr allanol	OMIM: 173870 HomoloGene: 1222 GeneCards: PARP1
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• transferase activity; • DNA binding; • R-SMAD binding; • DNA ligase (ATP) activity; • protein N-terminus binding; • glycosyltransferase activity; • NAD binding; • zinc ion binding; • transcription factor binding; • histone deacetylase binding; • metal ion binding; • GO:0001948, GO:0016582 protein binding; • identical protein binding; • protein kinase binding; • estrogen receptor binding; • enzyme binding; • SMAD binding; • RNA binding; • NAD+ ADP-ribosyltransferase activity; • protein ADP-ribosylase activity; • RNA polymerase II transcription regulatory region sequence-specific DNA binding; • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific; • NAD DNA ADP-ribosyltransferase activity;
Cydrannau o'r gell	• nuclear envelope; • bilen; • transcription regulator complex; • nucleoplasm; • nucleolus; • mitocondria; • cnewyllyn cell; • protein-DNA complex; • cytoplasm; • GO:0009327 protein-containing complex; • site of double-strand break; • site of DNA damage; • Cromosom;
Prosesau biolegol	• positive regulation of transcription regulatory region DNA binding; • lagging strand elongation; • GO:0009373 regulation of transcription, DNA-templated; • mitochondrial DNA metabolic process; • mitochondrial DNA repair; • nucleotide-excision repair, DNA damage recognition; • mitochondrion organization; • signal transduction involved in regulation of gene expression; • protein autoprocessing; • GO:1901227 negative regulation of transcription by RNA polymerase II; • transcription by RNA polymerase II; • macrophage differentiation; • cellular response to DNA damage stimulus; • positive regulation of cardiac muscle hypertrophy; • global genome nucleotide-excision repair; • double-strand break repair via homologous recombination; • protein modification process; • cellular response to insulin stimulus; • negative regulation of telomere maintenance via telomere lengthening; • protein poly-ADP-ribosylation; • cellular response to oxidative stress; • DNA ligation involved in DNA repair; • nucleotide-excision repair, DNA incision; • GO:0100026 DNA repair; • positive regulation of SMAD protein signal transduction; • nucleotide-excision repair, preincision complex assembly; • regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway; • cellular response to zinc ion; • regulation of SMAD protein complex assembly; • cellular response to amyloid-beta; • regulation of DNA methylation; • positive regulation of mitochondrial depolarization; • nucleotide-excision repair, DNA incision, 3'-to lesion; • positive regulation of intracellular estrogen receptor signaling pathway; • positive regulation of protein localization to nucleus; • nucleotide-excision repair, DNA incision, 5'-to lesion; • cellular response to transforming growth factor beta stimulus; • double-strand break repair; • transcription, DNA-templated; • positive regulation of myofibroblast differentiation; • nucleotide-excision repair, DNA duplex unwinding; • positive regulation of neuron death; • response to aldosterone; • transforming growth factor beta receptor signaling pathway; • nucleotide-excision repair, preincision complex stabilization; • response to gamma radiation; • GO:0048552 regulation of catalytic activity; • ATP generation from poly-ADP-D-ribose; • negative regulation of ATP biosynthetic process; • telomere maintenance; • protein ADP-ribosylation; • peptidyl-serine ADP-ribosylation; • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II; • GO:0097285 apoptotic process; • positive regulation of single strand break repair; • peptidyl-glutamic acid poly-ADP-ribosylation; • DNA ADP-ribosylation; • cellular response to UV; • protein auto-ADP-ribosylation; • positive regulation of double-strand break repair via homologous recombination;
	Sources:Amigo / QuickGO
Orthologau
	142
	n/a
	ENSG00000143799
	n/a
	P09874
	n/a
	NM_001618
	n/a
	NP_001609; NP_001609.2
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PARP1 yw PARP1 a elwir hefyd yn Poly [ADP-ribose] polymerase a Poly(ADP-ribose) polymerase 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 1, band 1q42.12.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PARP1.

PARP
PPOL
ADPRT
ARTD1
ADPRT1
PARP-1
ADPRT*1
pADPRT-1

Llyfryddiaeth

"Protein Poly(ADP-ribosyl)ation System: Changes in Development and Aging as well as due to Restriction of Cell Proliferation. ". Biochemistry (Mosc). 2017. PMID 29223166.
"Predictive value of epithelial-mesenchymal-transition (EMT) signature and PARP-1 in prostate cancer radioresistance. ". Prostate. 2017. PMID 29063620.
"Possible role of PAPR-1 in protecting human HaCaT cells against cytotoxicity of SiO2 nanoparticles. ". Toxicol Lett. 2017. PMID 28757444.
"The multifaceted roles of PARP1 in DNA repair and chromatin remodelling. ". Nat Rev Mol Cell Biol. 2017. PMID 28676700.
"Quantitative proteomic analysis of host epithelial cells infected by Salmonella enterica serovar Typhimurium.". Proteomics. 2017. PMID 28544771.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] PARP1 - Cronfa NCBI

[1]

[2]