PARN

PARN
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2A1R, 2A1S, 3CTR
Dynodwyr
Cyfenwau	PARN, DAN, DKCB6, PFBMFT4, Poly(A)-specific ribonuclease
Dynodwyr allanol	OMIM: 604212 HomoloGene: 31098 GeneCards: PARN
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • metal ion binding • mRNA 3'-UTR binding • GO:0001948, GO:0016582 protein binding • nucleic acid binding • nuclease activity • exonuclease activity • hydrolase activity • protein kinase binding • cation binding • RNA binding • poly(A)-specific ribonuclease activity • telomerase RNA binding • 3'-5'-exoribonuclease activity Cydrannau o'r gell • cytoplasm • cytosol • nucleolus • cnewyllyn cell Prosesau biolegol • mRNA catabolic process • female gamete generation • regulation of mRNA stability • GO:0016547 RNA modification • nuclear-transcribed mRNA catabolic process, nonsense-mediated decay • nuclear-transcribed mRNA poly(A) tail shortening • RNA phosphodiester bond hydrolysis, exonucleolytic • telomerase RNA stabilization • positive regulation of telomere maintenance via telomerase • positive regulation of telomerase activity • regulation of telomerase RNA localization to Cajal body • ncRNA deadenylation • box H/ACA RNA 3'-end processing • miRNA catabolic process • polyadenylation-dependent snoRNA 3'-end processing Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	5073	n/a
Ensembl	ENSG00000140694 ENSG00000274829	n/a
UniProt	O95453	n/a
RefSeq (mRNA)	NM_001134477 NM_001242992 NM_002582	n/a
RefSeq (protein)	NP_001127949 NP_001229921 NP_002573	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PARN yw PARN a elwir hefyd yn Poly(A)-specific ribonuclease (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 16, band 16p13.12.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PARN.

• DAN
• DKCB6
• PFBMFT4

Llyfryddiaeth

• "PARN Modulates Y RNA Stability and Its 3'-End Formation. ". Mol Cell Biol. 2017. PMID 28760775.
• "Rare Genetic Variants in PARN Are Associated with Pulmonary Fibrosis in Families. ". Am J Respir Crit Care Med. 2017. PMID 28414520.
• "Poly(A)-specific ribonuclease is a nuclear ribosome biogenesis factor involved in human 18S rRNA maturation. ". Nucleic Acids Res. 2017. PMID 28402503.
• "Poly(A)-specific ribonuclease regulates the processing of small-subunit rRNAs in human cells. ". Nucleic Acids Res. 2017. PMID 27899605.
• "Poly(A)-specific ribonuclease deficiency impacts telomere biology and causes dyskeratosis congenita.". J Clin Invest. 2015. PMID 25893599.