PARD6A

PARD6A
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1WMH
Dynodwyr
Cyfenwau	PARD6A, PAR-6A, PAR6, PAR6C, PAR6alpha, TAX40, TIP-40, par-6 family cell polarity regulator alpha
Dynodwyr allanol	OMIM: 607484 HomoloGene: 9661 GeneCards: PARD6A
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • transcription factor binding • GTP-dependent protein binding • GO:0001948, GO:0016582 protein binding • protein kinase C binding Cydrannau o'r gell • cytosol • cell projection • bilen • bicellular tight junction • ruffle • Cellbilen • cell cortex • cnewyllyn cell • cytoplasm • centrosome • microtubule organizing center • Cytosgerbwd • cell junction • centriolar satellite • GO:0009327 protein-containing complex • apical plasma membrane Prosesau biolegol • GO:0033128 negative regulation of protein phosphorylation • Cellraniad • cell-cell junction maintenance • bicellular tight junction assembly • cell cycle • GO:0022415 viral process • transforming growth factor beta receptor signaling pathway • Wnt signaling pathway, planar cell polarity pathway • positive regulation of protein localization to centrosome • centrosome cycle • establishment or maintenance of cell polarity • regulation of cellular localization • positive regulation of protein secretion Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	50855	n/a
Ensembl	ENSG00000102981	n/a
UniProt	Q9NPB6	n/a
RefSeq (mRNA)	NM_001037281 NM_016948	n/a
RefSeq (protein)	NP_001032358 NP_058644	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PARD6A yw PARD6A a elwir hefyd yn Par-6 family cell polarity regulator alpha (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 16, band 16q22.1.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PARD6A.

• PAR6
• PAR6C
• TAX40
• PAR-6A
• TIP-40
• PAR6alpha

Llyfryddiaeth

• "Rit mutants confirm role of MEK/ERK signaling in neuronal differentiation and reveal novel Par6 interaction. ". Biochim Biophys Acta. 2007. PMID 17976838.
• "Arterial shear stress regulates endothelial cell-directed migration, polarity, and morphology in confluent monolayers. ". Am J Physiol Heart Circ Physiol. 2007. PMID 17586613.
• "TGFβ-induced phosphorylation of Par6 promotes migration and invasion in prostate cancer cells. ". Br J Cancer. 2015. PMID 25756394.
• "Where polarity meets fusion: role of Par6 in trophoblast differentiation during placental development and preeclampsia. ". Endocrinology. 2013. PMID 23341197.
• "The polarity protein Par6 induces cell proliferation and is overexpressed in breast cancer.". Cancer Res. 2008. PMID 18922891.