PAPOLA

PAPOLA
Dynodwyr
Cyfenwau	PAPOLA, PAP, poly(A) polymerase alpha, PAP-alpha
Dynodwyr allanol	OMIM: 605553 HomoloGene: 23389 GeneCards: PAPOLA
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • transferase activity • nucleotide binding • nucleotidyltransferase activity • manganese ion binding • metal ion binding • GO:0001948, GO:0016582 protein binding • RNA binding • ATP binding • magnesium ion binding • polynucleotide adenylyltransferase activity Cydrannau o'r gell • cytoplasm • nucleoplasm • cnewyllyn cell Prosesau biolegol • mRNA splicing, via spliceosome • termination of RNA polymerase II transcription • RNA 3'-end processing • mRNA processing • mRNA polyadenylation • mRNA 3'-end processing • regulation of mRNA 3'-end processing • RNA polyadenylation Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	10914	n/a
Ensembl	ENSG00000090060	n/a
UniProt	P51003	n/a
RefSeq (mRNA)	NM_001252006 NM_001252007 NM_001293627 NM_001293628 NM_001293632 NM_032632 NM_001363662 NM_001363664 NM_001363665 NM_001363666	n/a
RefSeq (protein)	NP_001238935 NP_001238936 NP_001280556 NP_001280557 NP_001280561 NP_116021 NP_001350591 NP_001350593 NP_001350594 NP_001350595	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PAPOLA yw PAPOLA a elwir hefyd yn Poly(A) polymerase alpha (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 14, band 14q32.2.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PAPOLA.

• PAP

Llyfryddiaeth

• "Poly(A) Polymerase and the Nuclear Poly(A) Binding Protein, PABPN1, Coordinate the Splicing and Degradation of a Subset of Human Pre-mRNAs. ". Mol Cell Biol. 2015. PMID 25896913.
• "The NMR structure of the 38 kDa U1A protein - PIE RNA complex reveals the basis of cooperativity in regulation of polyadenylation by human U1A protein. ". Nat Struct Biol. 2000. PMID 10742179.
• "The structure of the 5'-untranslated region of mammalian poly(A) polymerase-alpha mRNA suggests a mechanism of translational regulation. ". Mol Cell Biochem. 2010. PMID 20174964.
• "Assignment of the human poly(A) polymerase (PAP) gene to chromosome 14q32.1-q32.2 and isolation of a polymorphic CA repeat sequence. ". J Hum Genet. 1999. PMID 10429366.
• "Binding of factor VIIa to tissue factor induces alterations in gene expression in human fibroblast cells: up-regulation of poly(A) polymerase.". Proc Natl Acad Sci U S A. 1997. PMID 9356495.