PAK6

PAK6
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2C30, 2ODB, 4KS8
Dynodwyr
Cyfenwau	PAK6, PAK5, p21 (RAC1) activated kinase 6
Dynodwyr allanol	OMIM: 608110 HomoloGene: 23200 GeneCards: PAK6
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • transferase activity • nucleotide binding • protein kinase activity • kinase activity • GO:0001948, GO:0016582 protein binding • ATP binding • cadherin binding • protein serine/threonine kinase activity Cydrannau o'r gell • cytoplasm • fibrillar center • cnewyllyn cell • cell junction Prosesau biolegol • GO:0009373 regulation of transcription, DNA-templated • phosphorylation • protein phosphorylation • cytoskeleton organization • GO:0097285 apoptotic process • Rho protein signal transduction • regulation of mitotic cell cycle • cell migration • GO:0072468 signal transduction • actin cytoskeleton organization • stress-activated protein kinase signaling cascade • activation of protein kinase activity • regulation of apoptotic process • regulation of MAPK cascade Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	56924	n/a
Ensembl	ENSG00000137843	n/a
UniProt	Q9NQU5	n/a
RefSeq (mRNA)	NM_020168 NM_001276717 NM_001276718 NM_001395430 NM_001395431	n/a
RefSeq (protein)	NP_001122100 NP_001122101	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PAK6 yw PAK6 a elwir hefyd yn Serine/threonine-protein kinase PAK 6 a P21 (RAC1) activated kinase 6 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 15, band 15q15.1.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PAK6.

• PAK5

Llyfryddiaeth

• "P21-activated kinase 5 plays essential roles in the proliferation and tumorigenicity of human hepatocellular carcinoma. ". Acta Pharmacol Sin. 2014. PMID 23685956.
• "Inhibition of p21-activated kinase 6 (PAK6) increases radiosensitivity of prostate cancer cells. ". Prostate. 2010. PMID 20054820.
• "Tumor Suppressive Function of p21-activated Kinase 6 in Hepatocellular Carcinoma. ". J Biol Chem. 2015. PMID 26442588.
• "PAK6 increase chemoresistance and is a prognostic marker for stage II and III colon cancer patients undergoing 5-FU based chemotherapy. ". Oncotarget. 2015. PMID 25426562.
• "Expression and prognostic significance of p21-activated kinase 6 in hepatocellular carcinoma.". J Surg Res. 2014. PMID 24576777.