PAK5

PAK5
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2F57
Dynodwyr
Cyfenwau	PAK5, PAK7, p21 (RAC1) activated kinase 7, p21 (RAC1) activated kinase 5
Dynodwyr allanol	OMIM: 608038 HomoloGene: 22211 GeneCards: PAK5
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • transferase activity • nucleotide binding • protein kinase activity • kinase activity • ATP binding • GO:0001948, GO:0016582 protein binding • protein serine/threonine kinase activity Cydrannau o'r gell • cytoplasm • mitocondria • cnewyllyn cell • nucleoplasm • synapse Prosesau biolegol • locomotory behavior • phosphorylation • negative regulation of extrinsic apoptotic signaling pathway • Cof • learning • protein phosphorylation • cytoskeleton organization • cell population proliferation • cell migration • GO:0072468 signal transduction • GO:0097285 apoptotic process • Rho protein signal transduction • regulation of mitotic cell cycle • actin cytoskeleton organization • stress-activated protein kinase signaling cascade • activation of protein kinase activity • regulation of apoptotic process • regulation of MAPK cascade • cell growth • regulation of cell growth Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	57144	n/a
Ensembl	ENSG00000101349	n/a
UniProt	Q9P286	n/a
RefSeq (mRNA)	NM_020341 NM_177990	n/a
RefSeq (protein)	NP_065074 NP_817127	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PAK5 yw PAK5 a elwir hefyd yn P21 (RAC1) activated kinase 5 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 20, band 20p12.2.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PAK5.

• PAK7

Llyfryddiaeth

• "p21-activated kinase 7 is an oncogene in human osteosarcoma. ". Cell Biol Int. 2014. PMID 25052921.
• "An oncogenic kinase: putting PAK5 forward. ". Expert Opin Ther Targets. 2014. PMID 24869804.
• "PAK5 is auto-activated by a central domain that promotes kinase oligomerization. ". Biochem J. 2016. PMID 27095851.
• "Over expression of p21-activated kinase 7 associates with lymph node metastasis in esophageal squamous cell cancers. ". Cancer Biomark. 2016. PMID 26682509.
• "Efficient inhibition of human glioma development by RNA interference-mediated silencing of PAK5.". Int J Biol Sci. 2015. PMID 25632266.