PAK2

PAK2
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 3PCS
Dynodwyr
Cyfenwau	PAK2, PAK65, PAKgamma, p21 (RAC1) activated kinase 2
Dynodwyr allanol	OMIM: 605022 HomoloGene: 99711 GeneCards: PAK2
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • transferase activity • protein kinase activity • nucleotide binding • protein tyrosine kinase activator activity • kinase activity • protein serine/threonine kinase activity • GO:0001948, GO:0016582 protein binding • catalytic activity • identical protein binding • ATP binding • protein kinase binding • cadherin binding • small GTPase binding Cydrannau o'r gell • bilen • Cellbilen • perinuclear region of cytoplasm • cnewyllyn cell • cytoplasm • cytosol • GO:0097483, GO:0097481 postsynaptic density • glutamatergic synapse Prosesau biolegol • negative regulation of protein kinase activity • phosphorylation • T cell costimulation • GO:1904579 cellular response to organic cyclic compound • stimulatory C-type lectin receptor signaling pathway • GO:0019049, GO:0030683 mitigation of host defenses by virus • Fc-epsilon receptor signaling pathway • protein phosphorylation • dendritic spine development • negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis • vascular endothelial growth factor receptor signaling pathway • GO:0035404 peptidyl-serine phosphorylation • positive regulation of peptidyl-tyrosine phosphorylation • positive regulation of extrinsic apoptotic signaling pathway • protein autophosphorylation • regulation of growth • metabolaeth • T cell receptor signaling pathway • GO:0072468 signal transduction • positive regulation of protein tyrosine kinase activity • GO:0097285 apoptotic process • negative regulation of apoptotic process • GO:0022415 viral process • Rho protein signal transduction • regulation of mitotic cell cycle • cell migration • actin cytoskeleton organization • stress-activated protein kinase signaling cascade • regulation of apoptotic process • regulation of MAPK cascade • interleukin-12-mediated signaling pathway • activation of protein kinase activity Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	5062	n/a
Ensembl	ENSG00000180370	n/a
UniProt	Q13177	n/a
RefSeq (mRNA)	NM_002577	n/a
RefSeq (protein)	NP_002568	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PAK2 yw PAK2 a elwir hefyd yn P21 (RAC1) activated kinase 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 3, band 3q29.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PAK2.

• PAK65
• PAKgamma

Llyfryddiaeth

• "Expansion of BCR/ABL1+ cells requires PAK2 but not PAK1. ". Br J Haematol. 2017. PMID 28707321.
• "Motility of select ovarian cancer cell lines: effect of extra-cellular matrix proteins and the involvement of PAK2. ". Int J Oncol. 2014. PMID 25050916.
• "Activation of P21-activated protein kinase 2 is an independent prognostic predictor for patients with gastric cancer. ". Diagn Pathol. 2014. PMID 24621074.
• "P21-activated protein kinase (PAK2)-mediated c-Jun phosphorylation at 5 threonine sites promotes cell transformation. ". Carcinogenesis. 2011. PMID 21177766.
• "Mechanistic studies of the autoactivation of PAK2: a two-step model of cis initiation followed by trans amplification.". J Biol Chem. 2011. PMID 21098037.