P4HB

P4HB
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1X5C, 1BJX, 2K18, 4JU5, 4EL1, 3BJ5, 1MEK, 2BJX, 3UEM, 4EKZ
Dynodwyr
Cyfenwau	P4HB, DSI, ERBA2L, GIT, P4Hbeta, PDI, PDIA1, PHDB, PO4DB, PO4HB, PROHB, CLCRP1, prolyl 4-hydroxylase subunit beta
Dynodwyr allanol	OMIM: 176790 HomoloGene: 55495 GeneCards: P4HB
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • isomerase activity • integrin binding • GO:0001948, GO:0016582 protein binding • procollagen-proline 4-dioxygenase activity • protein heterodimerization activity • enzyme binding • RNA binding • GO:0030508 protein disulfide isomerase activity Cydrannau o'r gell • procollagen-proline 4-dioxygenase complex • endoplasmic reticulum lumen • bilen • focal adhesion • melanosome • Cellbilen • endoplasmic reticulum chaperone complex • extracellular region • Reticwlwm endoplasmig • extracellular exosome • external side of plasma membrane • endoplasmic reticulum-Golgi intermediate compartment • GO:0005578 extracellular matrix Prosesau biolegol • positive regulation of viral entry into host cell • peptidyl-proline hydroxylation to 4-hydroxy-L-proline • regulation of oxidative stress-induced intrinsic apoptotic signaling pathway • cell redox homeostasis • response to endoplasmic reticulum stress • cellular response to hypoxia • protein folding • chylomicron assembly • very-low-density lipoprotein particle assembly • cellular response to oxidative stress • post-translational protein modification • interleukin-12-mediated signaling pathway • interleukin-23-mediated signaling pathway • cellular response to interleukin-7 Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	5034	n/a
Ensembl	ENSG00000185624	n/a
UniProt	P07237	n/a
RefSeq (mRNA)	NM_000918	n/a
RefSeq (protein)	NP_000909	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn P4HB yw P4HB a elwir hefyd yn Prolyl 4-hydroxylase subunit beta a Protein disulfide-isomerase (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 17, band 17q25.3.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn P4HB.

• DSI
• GIT
• PDI
• PHDB
• PDIA1
• PO4DB
• PO4HB
• PROHB
• CLCRP1
• ERBA2L
• P4Hbeta

Llyfryddiaeth

• "Advances in vascular thiol isomerase function.". Opin Hematol. 2017. PMID 28598864.
• "Kinetic-based trapping by intervening sequence variants of the active sites of protein-disulfide isomerase identifies platelet protein substrates.". J Biol Chem. 2017. PMID 28364042.
• "Red/ox states of human protein disulfide isomerase regulate binding affinity of 17 beta-estradiol.". Arch Biochem Biophys. 2017. PMID 28257787.
• "Protein disulfide isomerase externalization in endothelial cells follows classical and unconventional routes.". Free Radic Biol Med. 2017. PMID 28034831.
• "Polymorphisms in protein disulfide isomerase are associated with sporadic amyotrophic lateral sclerosis in the Chinese Han population.". Int J Neurosci. 2016. PMID 26000911.