P4HA1

P4HA1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1TJC, 2V5F, 2YQ8, 4BT8, 4BT9, 4BTA, 4BTB
Dynodwyr
Cyfenwau	P4HA1, P4HA, prolyl 4-hydroxylase subunit alpha 1
Dynodwyr allanol	OMIM: 176710 HomoloGene: 30998 GeneCards: P4HA1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • iron ion binding • L-ascorbic acid binding • oxidoreductase activity • GO:0001948, GO:0016582 protein binding • oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen • dioxygenase activity • procollagen-proline 4-dioxygenase activity • GO:0050602 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen • metal ion binding • identical protein binding Cydrannau o'r gell • procollagen-proline 4-dioxygenase complex • Reticwlwm endoplasmig • mitocondria • bilen • intracellular membrane-bounded organelle • endoplasmic reticulum lumen Prosesau biolegol • peptidyl-proline hydroxylation to 4-hydroxy-L-proline • collagen fibril organization Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	5033	n/a
Ensembl	ENSG00000122884	n/a
UniProt	P13674	n/a
RefSeq (mRNA)	NM_001142596 NM_000917 NM_001017962 NM_001142595	n/a
RefSeq (protein)	NP_000908 NP_001017962 NP_001136067 NP_001136068	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn P4HA1 yw P4HA1 a elwir hefyd yn Prolyl 4-hydroxylase subunit alpha 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 10, band 10q22.1.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn P4HA1.

• P4HA

Llyfryddiaeth

• "P4HA1 mutations cause a unique congenital disorder of connective tissue involving tendon, bone, muscle and the eye. ". Hum Mol Genet. 2017. PMID 28419360.
• "Prolyl 4-Hydroxylase: Substrate Isosteres in Which an (E)- or (Z)-Alkene Replaces the Prolyl Peptide Bond. ". Biochemistry. 2017. PMID 28001367.
• "Translational control of collagen prolyl 4-hydroxylase-alpha(I) gene expression under hypoxia. ". J Biol Chem. 2006. PMID 16837461.
• "Cigarette suppresses the expression of P4Halpha and vascular collagen production. ". Biochem Biophys Res Commun. 2004. PMID 15369792.
• "The order and transcriptional orientation of the human COL13A1 and P4HA genes on chromosome 10 long arm determined by high-resolution FISH.". Genomics. 1997. PMID 9417920.