OGG1

OGG1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1EBM, 1FN7, 1HU0, 1KO9, 1LWV, 1LWW, 1LWY, 1M3H, 1M3Q, 1N39, 1N3A, 1N3C, 1YQK, 1YQL, 1YQM, 1YQR, 2I5W, 2NOB, 2NOE, 2NOF, 2NOH, 2NOI, 2NOL, 2NOZ, 2XHI, 3IH7, 3KTU, 5AN4
Dynodwyr
Cyfenwau	OGG1, HMMH, HMUTM, OGH1, 8-oxoguanine DNA glycosylase
Dynodwyr allanol	OMIM: 601982 HomoloGene: 1909 GeneCards: OGG1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • DNA binding • microtubule binding • hydrolase activity, acting on glycosyl bonds • oxidized purine DNA binding • catalytic activity • GO:0001948, GO:0016582 protein binding • oxidized purine nucleobase lesion DNA N-glycosylase activity • lyase activity • endonuclease activity • 8-oxo-7,8-dihydroguanine DNA N-glycosylase activity • hydrolase activity • damaged DNA binding • DNA N-glycosylase activity • class I DNA-(apurinic or apyrimidinic site) endonuclease activity Cydrannau o'r gell • mitocondria • nuclear matrix • cnewyllyn cell • nuclear speck • nucleoplasm • GO:0009327 protein-containing complex Prosesau biolegol • depurination • nucleotide-excision repair • response to estradiol • GO:0009373 regulation of transcription, DNA-templated • response to light stimulus • GO:0010260 heneiddio • negative regulation of apoptotic process • cellular response to cadmium ion • GO:0001306 response to oxidative stress • depyrimidination • acute inflammatory response • response to radiation • response to folic acid • metabolaeth • response to ethanol • nucleotide-excision repair, DNA incision • negative regulation of double-strand break repair via single-strand annealing • base-excision repair • cellular response to DNA damage stimulus • GO:0100026 DNA repair • base-excision repair, AP site formation • telomere maintenance via telomerase Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	4968	n/a
Ensembl	ENSG00000114026	n/a
UniProt	O15527	n/a
RefSeq (mRNA)	NM_002542 NM_016819 NM_016820 NM_016821 NM_016826 NM_016827 NM_016828 NM_016829 NM_001354648 NM_001354649 NM_001354650 NM_001354651 NM_001354652	n/a
RefSeq (protein)	NP_002533 NP_058212 NP_058213 NP_058214 NP_058434 NP_058436 NP_058437 NP_058438 NP_001341577 NP_001341578 NP_001341579 NP_001341580 NP_001341581 NP_058436.1 NP_058434.1	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn OGG1 yw OGG1 a elwir hefyd yn 8-oxoguanine DNA glycosylase, isoform CRA_e , 8-oxoguanine DNA glycosylase, isoform CRA_k a 8-oxoguanine DNA glycosylase (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 3, band 3p25.3.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn OGG1.

• HMMH
• MUTM
• OGH1
• HOGG1

Llyfryddiaeth

• "β-8-Oxoguanine DNA Glycosylase Overexpression Reduces Oxidative Stress-Induced Mitochondrial Dysfunction and Apoptosis Through the JNK Signaling Pathway in Human Bronchial Epithelial Cells. ". DNA Cell Biol. 2017. PMID 29227732.
• "Human OGG1 activity in nucleosomes is facilitated by transient unwrapping of DNA and is influenced by the local histone environment. ". DNA Repair (Amst). 2017. PMID 28892740.
• "The mechanism of the glycosylase reaction with hOGG1 base-excision repair enzyme: concerted effect of Lys249 and Asp268 during excision of 8-oxoguanine. ". Nucleic Acids Res. 2017. PMID 28334993.
• "The levels of 7,8-dihydrodeoxyguanosine (8-oxoG) and 8-oxoguanine DNA glycosylase 1 (OGG1) - A potential diagnostic biomarkers of Alzheimer's disease. ". J Neurol Sci. 2016. PMID 27538622.
• "Correlating blood levels of 8-hydroxydeoxyguanosine to hOGG1 genotypes and the incidence of ischemic cardiomyopathy.". Kaohsiung J Med Sci. 2016. PMID 27316582.