NTRK2

NTRK2
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 4AT5, 1HCF, 1WWB, 2MFQ, 4ASZ, 4AT3, 4AT4
Dynodwyr
Cyfenwau	NTRK2, GP145-TrkB, TRKB, trk-B, neurotrophic receptor tyrosine kinase 2, OBHD, EIEE58
Dynodwyr allanol	OMIM: 600456 HomoloGene: 4504 GeneCards: NTRK2
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • neurotrophin binding • neurotrophin receptor activity • kinase activity • transmembrane receptor protein tyrosine kinase activity • ATP binding • protein kinase activity • brain-derived neurotrophic factor binding • transferase activity • protein homodimerization activity • protein tyrosine kinase activity • nucleotide binding • brain-derived neurotrophic factor-activated receptor activity • GO:0001948, GO:0016582 protein binding • receptor tyrosine kinase • transmembrane signaling receptor activity Cydrannau o'r gell • cytosol • endosome • postsynaptic membrane • bilen • terminal bouton • integral component of membrane • receptor complex • endosome membrane • integral component of plasma membrane • GO:0097483, GO:0097481 postsynaptic density • early endosome • early endosome membrane • Cellbilen • axon • dendrite • perinuclear region of cytoplasm • cytoplasm • cell projection • dendritic spine • axon terminus • Golgi membrane Prosesau biolegol • GO:1904089 negative regulation of neuron apoptotic process • peripheral nervous system neuron development • positive regulation of protein phosphorylation • oligodendrocyte differentiation • learning • positive regulation of axonogenesis • vasculogenesis • protein phosphorylation • central nervous system neuron development • neuromuscular junction development • retinal rod cell development • Rhythm circadaidd • feeding behavior • GO:0043087, GO:0032313, GO:0032319, GO:0032314, GO:0043088 regulation of GTPase activity • positive regulation of peptidyl-serine phosphorylation • brain-derived neurotrophic factor receptor signaling pathway • regulation of protein kinase B signaling • regulation of metabolic process • positive regulation of MAPK cascade • cell differentiation • phosphorylation • neuron migration • mechanoreceptor differentiation • nervous system development • glutamate secretion • retina development in camera-type eye • neuron differentiation • cerebral cortex development • negative regulation of anoikis • multicellular organism development • GO:1901313 positive regulation of gene expression • positive regulation of cell population proliferation • positive regulation of neuron projection development • cellular response to amino acid stimulus • positive regulation of phosphatidylinositol 3-kinase signaling • peptidyl-tyrosine phosphorylation • long-term potentiation • positive regulation of synapse assembly • transmembrane receptor protein tyrosine kinase signaling pathway • protein autophosphorylation • trans-synaptic signaling by neuropeptide, modulating synaptic transmission • activation of phospholipase C activity • neurotrophin TRK receptor signaling pathway • positive regulation of non-membrane spanning protein tyrosine kinase activity • trans-synaptic signaling by BDNF, modulating synaptic transmission • negative regulation of signal transduction • neuronal action potential propagation • myelination in peripheral nervous system • negative regulation of apoptotic process • positive regulation of ERK1 and ERK2 cascade • cellular response to nerve growth factor stimulus • regulation of MAPK cascade • cellular response to brain-derived neurotrophic factor stimulus Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	4915	n/a
Ensembl	ENSG00000148053	n/a
UniProt	Q16620	n/a
RefSeq (mRNA)	NM_001007097 NM_001018064 NM_001018065 NM_001018066 NM_001291937 NM_006180	n/a
RefSeq (protein)	NP_001007098 NP_001018074 NP_001018075 NP_001018076 NP_001278866 NP_006171 NP_001356461 NP_001356462 NP_001356463 NP_001356464 NP_001356465 NP_001356466 NP_001356467 NP_001356468 NP_001356469 NP_001356470 NP_001356471 NP_001356472 NP_001356473 NP_001356474 NP_001356475 NP_001356476 NP_001356477 NP_001356478 NP_001356479 NP_001356480 NP_001356481	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn NTRK2 yw NTRK2 a elwir hefyd yn Neurotrophic receptor tyrosine kinase 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 9, band 9q21.33.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn NTRK2.

• OBHD
• TRKB
• trk-B
• GP145-TrkB

Llyfryddiaeth

• "7,8-Dihydroxyflavone ameliorates high-glucose induced diabetic apoptosis in human retinal pigment epithelial cells by activating TrkB. ". Biochem Biophys Res Commun. 2018. PMID 29109000.
• "Tyrosine receptor kinase B is a drug target in astrocytomas. ". Neuro Oncol. 2017. PMID 27402815.
• "A common NTRK2 variant is associated with emotional arousal and brain white-matter integrity in healthy young subjects. ". Transl Psychiatry. 2016. PMID 26978740.
• "Tyrosine receptor kinase B silencing inhibits anoikis‑resistance and improves anticancer efficiency of sorafenib in human renal cancer cells. ". Int J Oncol. 2016. PMID 26820170.
• "Entrectinib is a potent inhibitor of Trk-driven neuroblastomas in a xenograft mouse model.". Cancer Lett. 2016. PMID 26797418.