NSD3

NSD3
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2DAQ, 4GND, 4GNE, 4GNF, 4GNG, 4RXJ, 4YZ8, 2ND1, 2NCZ
Dynodwyr
Cyfenwau	NSD3, pp14328, WHSC1L1, WHISTLE, Wolf-Hirschhorn syndrome candidate 1-like 1, nuclear receptor binding SET domain protein 3, KMT3G, KMT3F
Dynodwyr allanol	OMIM: 607083 HomoloGene: 56960 GeneCards: NSD3
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0102674, GO:0102675 methyltransferase activity • transferase activity • GO:0001948, GO:0016582 protein binding • metal ion binding • histone-lysine N-methyltransferase activity • GO:0001105 transcription coactivator activity • histone methyltransferase activity (H3-K36 specific) Cydrannau o'r gell • cnewyllyn cell • nucleoplasm • Cromosom • chromatin Prosesau biolegol • histone methylation • methylation • GO:0009373 regulation of transcription, DNA-templated • transcription, DNA-templated • histone lysine methylation • GO:0031497, GO:0006336, GO:0034724, GO:0001301, GO:0007580, GO:0034652, GO:0010847 chromatin organization • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • positive regulation of histone H3-K36 trimethylation • histone H3-K36 methylation Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	54904	n/a
Ensembl	ENSG00000147548	n/a
UniProt	Q9BZ95	n/a
RefSeq (mRNA)	NM_017778 NM_023034	n/a
RefSeq (protein)	NP_060248 NP_075447	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn NSD3 yw NSD3 a elwir hefyd yn Nuclear receptor binding SET domain protein 3 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 8, band 8p11.23.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn NSD3.

• KMT3F
• KMT3G
• WHISTLE
• WHSC1L1
• pp14328

Llyfryddiaeth

• "NSD3, a new SET domain-containing gene, maps to 8p12 and is amplified in human breast cancer cell lines. ". Genomics. 2001. PMID 11374904.
• "Amplification of WHSC1L1 regulates expression and estrogen-independent activation of ERα in SUM-44 breast cancer cells and is associated with ERα over-expression in breast cancer. ". Mol Oncol. 2016. PMID 27005559.
• "The histone methyltransferase Wolf-Hirschhorn syndrome candidate 1-like 1 (WHSC1L1) is involved in human carcinogenesis. ". Genes Chromosomes Cancer. 2013. PMID 23011637.
• "The NSD3L histone methyltransferase regulates cell cycle and cell invasion in breast cancer cells. ". Biochem Biophys Res Commun. 2010. PMID 20599755.
• "High-resolution genomic profiles of human lung cancer.". Proc Natl Acad Sci U S A. 2005. PMID 15983384.